Chiara F.
- Country
- Italy
- Department
- Hematology
Research Overview
- Phase 3 Randomized Double-Blind Placebo-Controlled Study of Mavorixafor in Chronic Neutropenia with Recurrent or Serious Infections
- Evaluation of Allogeneic Hematopoietic Stem Cell Transplantation with Azacitidine Versus Conventional Chemotherapy in High-Risk Myelodysplastic Syndromes
- Evaluation of Pozelimab and Cemdisiran Combination Therapy Versus Ravulizumab and Eculizumab in Complement Inhibitor-Naive Paroxysmal Nocturnal Hemoglobinuria Patients
Data & Insights
Has run more than one trial at 38 of 127 partner sites.
Specializations
Hematologic malignancies and cellular therapy
Chiara Frairia is involved in clinical research on a wide spectrum of blood cancers, with a strong focus on acute leukemias, chronic lymphocytic leukemia, myelodysplastic syndromes, and aggressive non-Hodgkin lymphomas. Her work also extends to multiple myeloma, Hodgkin lymphoma, myelofibrosis, and marginal zone lymphoma, alongside studies in CAR T-cell therapy, bispecific antibodies, and post-transplant disease control.
- Acute myeloid leukemia and acute lymphoblastic leukemia
- Diffuse large B-cell lymphoma and related B-cell neoplasms
- Multiple myeloma and plasma cell dyscrasias
- Stem cell transplantation and graft-versus-host disease
Her trial portfolio includes therapies for relapsed, refractory, and newly diagnosed hematologic cancers, with particular attention to immune-based and targeted treatment strategies in the transplant and post-transplant setting.
Pediatric oncology and rare solid tumors
Her clinical research landscape includes pediatric and adolescent malignancies such as high-risk neuroblastoma, medulloblastoma, glioblastoma, ependymoma, rhabdomyosarcoma, and atypical teratoid/rhabdoid tumor. She is also involved in studies addressing relapsed or refractory solid tumors and molecularly defined pediatric cancers.
- Pediatric brain tumors and high-grade glioma
- Neuroblastoma and sarcoma
- Relapsed/refractory pediatric cancers
- Molecularly targeted oncology in young patients
Her involvement spans innovative treatment approaches for children and young adults with difficult-to-treat cancers, including regimens designed around tumor biology and refractory disease patterns.
Autoimmune, inflammatory, and hematologic immune disorders
Chiara Frairia is active in trials for immune-mediated conditions including immune thrombocytopenia, antiphospholipid syndrome, myasthenia gravis, systemic sclerosis-associated interstitial lung disease, hidradenitis suppurativa, and ulcerative colitis. Her research also covers chronic inflammatory states such as recurrent pericarditis and idiopathic inflammatory myopathies.
- Immune thrombocytopenia and thrombotic microangiopathy
- Autoimmune connective tissue disease
- Inflammatory skin disease and immune-mediated dermatology
- Inflammatory cardiology and serosal disease
Her therapeutic interests include immune modulation, relapse prevention, and control of persistent inflammation across hematologic and non-hematologic immune disorders.
Metabolic, hepatic, and cardiovascular disease
Her trial activity also includes non-alcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis, cirrhosis, heart failure, atrial fibrillation, myocardial infarction, and hypertension. Additional interests include chronic kidney disease, proteinuria, and thromboembolic disease.
- NASH and MASH
- Heart failure and atherothrombotic cardiovascular disease
- Arrhythmia and thrombosis prevention
- Kidney disease with metabolic or vascular comorbidity
Her research profile reflects interest in therapies that address chronic organ injury, cardiometabolic risk, and progressive liver disease in patients with complex multisystem conditions.
Respiratory, neurologic, and ophthalmic disorders
She is involved in studies across chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, amyotrophic lateral sclerosis, multiple sclerosis, Alzheimer’s disease, and glaucoma. Her portfolio also includes conditions such as migraine, Parkinson’s disease, and diabetic macular edema.
- Interstitial lung disease and fibrotic lung disorders
- Neurodegenerative disease
- Demyelinating disease and neuromuscular disorders
- Retinal disease and optic nerve disorders
Her clinical research interests include treatment pathways for progressive chronic diseases in which symptom control, functional preservation, and organ protection are central therapeutic goals.
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