Charlotte Z.
- Country
- The Netherlands
- Department
- Head and Neck surgery
Research Overview
- Evaluation of Transtympanic Sodium Thiosulfate for Prevention of Cisplatin-Induced Ototoxicity in Patients with Head and Neck Squamous Cell Carcinoma
- Evaluation of Ipilimumab and Nivolumab in Immunotherapy for Cutaneous Squamous Cell Carcinoma in Patients Typically Undergoing Surgery and Radiotherapy
- IMCISION: Towards organ preservation and cure via ultra-short immunotherapy in advanced oral cancer. The IMCISION II trial, an investigator-initiated multicentre randomised phase 3 trial (M24IMS)
Data & Insights
Has run more than one trial at 4 of 10 partner sites.
Specializations
Head and Neck Oncology
Focused on malignancies of the upper aerodigestive tract and related structures.
- Head and Neck Squamous Cell Carcinoma
- Salivary Gland Carcinoma
- Oral Cavity Cancer
- Thyroid Carcinoma
- HPV‑Associated Oropharyngeal Cancer
Therapeutic strategies include multimodal surgery, radiation, and emerging immuno‑oncology approaches.
Thoracic and Pulmonary Malignancies
Investigations target primary lung cancers and related molecular subtypes.
- Non‑Small Cell Lung Cancer
- Small Cell Lung Carcinoma
- ALK‑Positive NSCLC
- KRAS G12C‑Mutant Lung Cancer
- EGFR‑Mutated NSCLC
Emphasis on targeted kinase inhibitors and checkpoint inhibitor combinations.
Gynecologic and Urologic Cancers
Research addresses malignancies of the reproductive and urinary tracts.
- Cervical Squamous Cell Carcinoma
- Vulvar Squamous Cell Carcinoma
- Endometrial Carcinoma
- Muscle‑Invasive Bladder Cancer
- Urothelial Carcinoma
Clinical programs incorporate neoadjuvant immunotherapy and bladder‑preserving regimens.
Gastrointestinal and Hepatobiliary Tumors
Focus on cancers of the digestive system and biliary tree.
- Colorectal Carcinoma
- Gastric Adenocarcinoma
- Pancreatic Ductal Adenocarcinoma
- Cholangiocarcinoma
- Neuroendocrine Tumors
Efforts include biomarker‑driven therapies and multimodal treatment sequencing.
Rare and Molecularly Defined Solid Tumors
Investigation of low‑incidence cancers and tumors with specific genetic alterations.
- Malignant Pleural Mesothelioma
- Renal Cell Carcinoma
- High‑Grade Sarcomas
- MSI‑High / dMMR Tumors
- TMB‑High Solid Tumors
Clinical activity centers on immunotherapy, PARP inhibition, and novel targeted agents.
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