Hélène C.
- Country
- France
- Department
- Anaesthesia and Intensive Care
Research Overview
- Effect of Adjuvant Ketamine on Recovery from Critical Illness in Adult Patients Requiring Unplanned Invasive Mechanical Ventilation: A Multicenter Randomized Controlled Trial
- Continuation vs Discontinuation of Dapagliflozin (SGLT‑2 inhibitor) in Heart Failure Patients Undergoing Cardiac Surgery: 30‑Day Cardiovascular Outcomes (DISCO Study)
- ARTEMIS: RAvulizumab to PRotect PaTients with Chronic Kidney DisEase (CKD) froM Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) and Subsequent Major Adverse Kidney Events (MAKE): A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study
Data & Insights
Has run more than one trial at 2 of 59 partner sites.
Specializations
Anesthesiology and Intensive Care Medicine
Clinical research in anesthesiology and critical care includes recovery after unplanned invasive mechanical ventilation in the ICU, along with perioperative and post-intensive care management.
- Critical illness recovery
- Mechanical ventilation
- Perioperative intensive care
Work in this area is centered on improving outcomes for severely ill adults requiring advanced respiratory support and close postoperative monitoring.
Cardiovascular and Antithrombotic Therapy
Research interests include atrial fibrillation, stroke prevention, cardiovascular risk, transcatheter aortic valve implantation, acute coronary syndrome, and management of hypertension and ventricular ectopy.
- Atrial fibrillation
- Stroke and systemic embolism prevention
- Transcatheter aortic valve implantation
- Cardiovascular prevention
The therapeutic focus also extends to anticoagulation, antiplatelet therapy, and prevention of bleeding and thromboembolic complications in high-risk cardiac settings.
Oncology and Genitourinary Cancer
Major activity is seen in prostate cancer, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, colorectal cancer, cervical cancer, anal cancer, and pancreatic ductal adenocarcinoma.
- Prostate cancer
- Breast cancer
- Ovarian cancer
- Head and neck cancer
Therapeutic interests include endocrine therapy, androgen receptor–targeted treatment, HER2-directed therapy, immunotherapy, and radiotherapy in localized, advanced, and recurrent disease.
Gastroenterology and Hepatology
Clinical research covers Crohn’s disease, ulcerative colitis, primary biliary cholangitis, metabolic dysfunction-associated steatotic liver disease, nonalcoholic steatohepatitis, and obesity-associated inflammatory disease.
- Inflammatory bowel disease
- Cholestatic liver disease
- Steatotic liver disease
- Metabolic disease
The therapeutic landscape includes biologic treatment, metabolic modulation, and liver-directed strategies for chronic inflammatory and fibrotic disease.
Perioperative and Structural Intervention
Additional interests include prevention of acute kidney injury after cardiac surgery, optimization of care after colorectal surgery, and antithrombotic management in patients with aortic valve disease or bioprosthetic valves.
- Cardiac surgery complications
- Colorectal surgery
- Valve disease management
This area also includes interest in infection prevention and postoperative cardiovascular protection in complex surgical populations.
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