Cécile P. L.
- Country
- France
- Department
- Service d'Oncologie médicale
Research Overview
- A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate Pembrolizumab Versus Placebo as Adjuvant Therapy Following Surgery and Radiation in Participants with High-risk Locally Advanced Cutaneous Squamous Cell Carcinoma (LA cSCC) (KEYNOTE-630).
- Evaluation of Pembrolizumab, Quavonlimab, and Lenvatinib in Advanced Melanoma with Brain Metastases: A Phase 1/2 Open-Label Study
- Evaluation of Pembrolizumab, Lenvatinib, Tretinoin, Vibostolimab, and Quavonlimab in PD-1 Refractory Melanoma: A Phase 1/2 Open-label Study
Data & Insights
Has run more than one trial at 92 of 206 partner sites.
Specializations
Breast Cancer and HER2-Directed Oncology
Clinical research in medical oncology with a strong focus on breast cancer, including hormone receptor-positive disease, HER2-negative and HER2-positive subtypes, triple-negative breast cancer, and metastatic or locally advanced presentations.
- Hormone receptor-positive breast cancer
- HER2-positive and HER2-low breast cancer
- Triple-negative breast cancer
- Metastatic breast cancer
Interest also extends to biomarker-informed treatment selection and targeted approaches in recurrent, high-risk, and endocrine-resistant breast cancer.
Lung Cancer and Thoracic Malignancies
Active involvement in non-small cell lung cancer, small cell lung cancer, and other thoracic tumors, with attention to advanced, unresectable, and metastatic disease as well as biomarker-defined subgroups.
- Non-small cell lung cancer
- Small cell lung cancer
- Mesothelioma
- Head and neck squamous cell carcinoma
Therapeutic interest includes immune-based and targeted strategies for lung and thoracic cancers carrying actionable genomic alterations.
Hematologic Malignancies and Cellular Therapy
Research activity includes acute leukemia, myelodysplastic syndromes, multiple myeloma, and lymphoma, with participation across both aggressive and relapsed or refractory blood cancers.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Multiple myeloma
- Diffuse large B-cell lymphoma
The investigator is also involved in studies relevant to allogeneic hematopoietic stem cell transplantation and novel immunotherapeutic strategies in hematologic disease.
Gastrointestinal, Hepatobiliary, and Rare Solid Tumors
Clinical interests cover colorectal cancer, gastric cancer, pancreatic cancer, hepatocellular carcinoma, and biliary tract cancer, alongside rarer solid tumors such as sarcomas, neuroendocrine tumors, and chondrosarcoma.
- Colorectal cancer
- Pancreatic adenocarcinoma
- Hepatocellular carcinoma
- Sarcoma and neuroendocrine tumors
This area also includes interest in biomarker-driven treatment for advanced solid tumors and rare malignancies with limited standard options.
Autoimmune, Inflammatory, and Immune-Mediated Disorders
The investigator is engaged in trials involving systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, psoriatic arthritis, and vasculitis, reflecting a parallel therapeutic focus beyond oncology.
- Systemic lupus erythematosus
- Lupus nephritis
- Rheumatoid arthritis
- ANCA-associated vasculitis
Additional interest includes inflammatory bowel disease, hidradenitis suppurativa, and other immune-mediated conditions requiring targeted immunomodulation.
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