Catharina F.
- Country
- The Netherlands
- Department
- Neurology
Research Overview
- Efficacy and Safety of DYNE-101 in Participants with Myotonic Dystrophy Type 1: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study
- Evaluation of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VX-670 in Adult Patients with Myotonic Dystrophy Type 1: A Phase 1/2 Randomized, Double-Blind, Placebo-Controlled Study
- Evaluation of the Efficacy and Safety of Intravenous AOC 1001 in Myotonic Dystrophy Type 1: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 15 of 33 partner sites.
Specializations
Neurovascular and Cerebrovascular Medicine
Clinical research activity includes ischemic stroke, transient ischemic attack, acute coronary syndrome, and thrombolysis-related care, with attention to urgent treatment decisions and secondary prevention in neurology.
- Stroke
- Transient ischemic attack
- Acute ischemic stroke
- Antithrombotic therapy
Interest also extends to vascular complications linked to anticoagulant use and bleeding risk in time-sensitive neurological and cardiovascular settings.
Neurodegenerative and Movement Disorders
Research involvement covers refractory epilepsy, Menière's disease, spinocerebellar ataxia, Huntington's disease, and myotonic dystrophy, reflecting a focus on chronic neurological disorders with functional and symptomatic burden.
- Refractory epilepsy
- Menière's disease
- Spinocerebellar ataxia
- Huntington's disease
Additional activity includes disorders affecting balance, motor control, and neuromuscular function.
Neuro-oncology
Clinical trial participation includes glioblastoma, high-grade glioma, astrocytoma, brain metastases, and central nervous system lymphoma, with a strong therapeutic interest in difficult-to-treat intracranial malignancies.
- Glioblastoma
- Brain metastases
- Central nervous system lymphoma
- High-grade glioma
This area also includes advanced solid tumors with neurological involvement and treatment-resistant disease.
Cardiovascular and Cardiorenal Disease
Research spans heart failure, hypertrophic cardiomyopathy, atrial fibrillation, peripheral arterial disease, and acute kidney injury, alongside broader interest in cardiovascular risk reduction and cardiorenal protection.
- Heart failure
- Hypertrophic cardiomyopathy
- Atrial fibrillation
- Acute kidney injury
Related activity includes management of vascular disease, structural heart conditions, and kidney-related complications in cardiovascular care.
Supportive and Symptom-Directed Neurology
Investigational work also addresses xerostomia, fatigue, fibromyalgia, post-craniotomy headache, and quality of life in patients with chronic or advanced illness, linking neurological care with symptom relief and supportive treatment.
- Xerostomia
- Fatigue
- Fibromyalgia
- Post-craniotomy headache
There is also involvement in treatment areas affecting frailty, palliative needs, and functional outcomes in neurologically vulnerable populations.
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