Catarina A.
- Country
- Portugal
- Department
- Oncology
Research Overview
- Sotorasib and Combination Therapy Versus Standard Chemotherapy in Treatment-Naïve Patients with KRAS p.G12C-Mutated Metastatic Colorectal Cancer
- Phase 3 Randomized Study of Adagrasib and Cetuximab Versus Chemotherapy in Advanced Colorectal Cancer with KRAS G12C Mutation Post-First-Line Therapy
- Phase 3 Randomized, Double-blind, Placebo-controlled Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Gastrointestinal, Pancreatic, or Colorectal Cancer
Data & Insights
Has run more than one trial at 305 of 615 partner sites.
Specializations
Medical Oncology
The clinical research profile is strongly centered on solid tumors and hematologic malignancies, with active involvement in treatment strategies for breast cancer, non-small cell lung cancer, colorectal cancer, gastric and gastroesophageal junction cancer, head and neck squamous cell carcinoma, bladder cancer, ovarian cancer, and prostate cancer.
- Breast cancer
- Non-small cell lung cancer
- Colorectal cancer
- Hematologic malignancies
- Head and neck cancer
Research activity also includes therapies for advanced and metastatic disease, HER2-positive and HER2-low breast cancer, and KRAS G12C-mutant tumors.
Immune-Mediated and Inflammatory Diseases
Another major area of interest is autoimmune disease and chronic inflammatory conditions, including systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, psoriatic arthritis, psoriasis, and inflammatory bowel disease.
- Systemic lupus erythematosus
- Sjögren’s syndrome
- Inflammatory bowel disease
- Psoriatic arthritis
- Atopic dermatitis
Therapeutic involvement also extends to hidradenitis suppurativa, giant cell arteritis, systemic sclerosis, and myasthenia gravis.
Neurology and Neurodegenerative Disorders
The investigator is engaged in clinical research on neurological disorders spanning epilepsy, migraine, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, and broader neurodegenerative diseases.
- Multiple sclerosis
- Epilepsy
- Migraine
- Parkinson’s disease
- Alzheimer’s disease
This portfolio also includes work in amyotrophic lateral sclerosis, frontotemporal dementia, Huntington’s disease, and spinocerebellar ataxia.
Cardiovascular, Renal, and Metabolic Medicine
Clinical interests further cover cardiovascular disease, heart failure, atrial fibrillation, atherosclerotic cardiovascular disease, stroke prevention, and valvular heart disease, alongside kidney disease and glomerular disorders.
- Heart failure
- Atrial fibrillation
- Chronic kidney disease
- Focal segmental glomerulosclerosis
- Stroke prevention
Research activity also includes obesity, type 2 diabetes, non-alcoholic steatohepatitis, hypertension, and hypercholesterolemia.
Pulmonary, Gastrointestinal, and Rare Diseases
Additional therapeutic interests include asthma, chronic obstructive pulmonary disease, pulmonary arterial hypertension, bronchiectasis, and interstitial lung disease, as well as gastrointestinal and hepatobiliary disorders.
- Pulmonary arterial hypertension
- Asthma
- Chronic obstructive pulmonary disease
- Inflammatory bowel disease
- Wilson disease
The portfolio also reaches cystic fibrosis, hereditary transthyretin amyloidosis, myasthenic syndromes, and rare metabolic disorders.
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