Jean Z.
- Country
- France
- Department
- Oncologie Médicale
Research Overview
- Phase 1a/1b Study of CDK4 Inhibitor BGB-43395 in Metastatic HR+/HER2- Breast Cancer and Advanced Solid Tumors
- Phase 3 Randomized Study of BGB‑43395 + Letrozole versus CDK4/6 Inhibitor Combination + Letrozole in Treatment‑Naïve Advanced HR+/HER2‑ Breast Cancer
- Efficacy and Safety Comparison of Obinutuzumab-Venetoclax vs. Obinutuzumab-Chlorambucil in Untreated CLL with Comorbidities
Data & Insights
Has run more than one trial at 63 of 228 partner sites.
Specializations
Myeloproliferative Neoplasms and Acute Leukemia
Clinical research activity includes myelofibrosis, essential thrombocythaemia, acute myeloid leukemia, and Philadelphia chromosome-positive chronic myelogenous leukemia, with interest in both treatment-resistant disease and first-line hematologic management.
- Relapsed or refractory multiple myeloma
- Chronic lymphocytic leukemia
- Diffuse large B-cell lymphoma
- Mantle cell lymphoma
The investigator is also involved in lymphoid malignancies and therapies aimed at disease control after prior treatment exposure.
Inflammatory Bowel Disease and Autoimmune Disorders
Research interests extend to Crohn’s disease, ulcerative colitis, systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, and systemic sclerosis, reflecting a strong focus on immune-mediated disease.
- Moderately to severely active Crohn’s disease
- Moderately to severely active ulcerative colitis
- Idiopathic inflammatory myopathy
- Generalized myasthenia gravis
Therapeutic activity also includes primary progressive multiple sclerosis and relapsing multiple sclerosis, alongside broader autoimmune neurologic disease management.
Gastrointestinal and Liver Disease
The investigator participates in studies across non-alcoholic steatohepatitis, hepatocellular carcinoma, cholangiocarcinoma, biliary tract cancer, and primary biliary cholangitis, with a clear emphasis on hepatic and hepatobiliary therapeutics.
- Chronic hepatitis C virus infection
- Chronic hepatitis D infection
- Gastric and gastroesophageal junction cancer
- Colorectal cancer
Additional involvement includes gastroesophageal adenocarcinoma and pancreatic cancer, supporting a broad gastrointestinal oncology profile.
Hemostasis, Thrombosis, and Cardiovascular Disease
Clinical interests include haemophilia A and B, primary immune thrombocytopenia, chemotherapy-induced thrombocytopenia, atrial fibrillation, and atherosclerotic cardiovascular disease, linking bleeding disorders with thrombotic and vascular prevention.
- Anticoagulation reversal
- Major adverse cardiovascular events
- Hypertension
- Chronic kidney disease
Research also covers hyperkalaemia and cardiovascular risk reduction in patients with complex comorbidity profiles.
Rare Genetic, Neurologic, and Infectious Diseases
Additional trial involvement spans Fabry disease, chronic inflammatory demyelinating polyneuropathy, neurogenic detrusor overactivity, refractory partial onset epilepsy, and multiple sclerosis, showing engagement with uncommon neurologic and inherited conditions.
- Chronic hepatitis D virus infection
- COVID-19
- Severe community-acquired bacterial pneumonia
- Secondary immunodeficiency
The investigator also participates in studies addressing infection prevention and supportive care in hematologic disease.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.