Carsten E.
- Country
- Germany
- Department
- Neurologie
Research Overview
- Evaluation of Intestinal Gel Therapy with Levodopa, Entacapone, and Carbidopa Monohydrate in Parkinson's Disease to Mitigate Dopaminergic Desensitization and Neuropsychiatric Complications
- Evaluation of Intravenous Thrombolysis with Alteplase or Tenecteplase in Acute Ischemic Stroke Patients on Direct Oral Anticoagulants
Data & Insights
Has run more than one trial at 0 of 80 partner sites.
Specializations
Acute Stroke and Thrombolysis
Neurology research includes treatment strategies for acute ischemic stroke, with attention to patients who have recently taken direct oral anticoagulants and require urgent reperfusion care.
- Intravenous thrombolysis in anticoagulated stroke
- Functional recovery after acute stroke
- Reperfusion treatment in emergency neurology
Clinical activity in this area is centered in Bottrop at Knappschaft Kliniken Bottrop GmbH and Marienhospital Bottrop gGmbH.
Early Breast Cancer
The investigator is involved in early breast cancer research across hormone receptor-positive, HER2-negative, and HER2-positive disease, with interest in recurrence prevention and adjuvant treatment optimization.
- Adjuvant endocrine therapy
- CDK4/6 inhibitor-based treatment
- Risk-adapted therapy in high-risk disease
This includes work in ER+/HER2- breast cancer, node-positive disease, and patients with elevated relapse risk after standard treatment.
Advanced and Metastatic Breast Cancer
Research activity also extends to locally advanced and metastatic breast cancer, including HER2-low, triple-negative breast cancer, and tumors with PIK3CA or BRCA pathway alterations.
- Targeted therapy in metastatic breast cancer
- Antibody-drug conjugate treatment
- Precision oncology for biomarker-defined disease
Therapeutic interests include HER2-positive and HER2-negative advanced disease, endocrine-resistant breast cancer, and biomarker-driven treatment selection.
Post-treatment Recurrence Prevention and Biomarker-Guided Care
The investigator is engaged in studies focused on minimal residual disease, ctDNA-guided management, and recurrence prevention after initial breast cancer therapy.
- Molecular relapse detection
- Biomarker-guided adjuvant treatment
- Genomic risk stratification
This area includes interest in HER2DX-guided treatment, germline mutation-associated disease, and strategies for reducing distant recurrence.
Supportive and Neurodegenerative Care
Beyond oncology, the investigator also contributes to research in Parkinson disease and treatment-related symptom control, including management of vasomotor symptoms associated with endocrine therapy.
- Parkinson disease symptom management
- Levodopa-based therapy
- Endocrine therapy-related hot flashes
These interests reflect involvement in both movement disorders and supportive care for patients receiving long-term cancer treatment.
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