Carolin O.
- Country
- Germany
- Department
- Klinik für Neurologie
Research Overview
- Efficacy of efgartigimod alfa as add‑on to intravenous methylprednisolone for moderate‑to‑severe attacks in patients with multiple sclerosis, NMOSD or MOGAD
- Long-term Safety and Efficacy Evaluation of Ocrelizumab in Multiple Sclerosis Patients from Phase III Studies
- Evaluation of Efficacy, Safety, and Pharmacokinetics of Increased Ocrelizumab Dose in Adults with Relapsing Multiple Sclerosis: A Phase IIIb Randomized Controlled Trial
Data & Insights
Has run more than one trial at 95 of 230 partner sites.
Specializations
Neurodegenerative and movement disorders
Clinical research activity includes Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, progressive supranuclear palsy, and stiff person syndrome, with interest in conditions affecting cognition, motor function, and long-term neurological disability.
- Alzheimer’s disease
- Parkinson’s disease
- Multiple sclerosis
- Amyotrophic lateral sclerosis
- Huntington’s disease
Additional involvement extends to cognitive impairment, dementia, seizure disorders, and neuromuscular disease.
Autoimmune and inflammatory neurological disease
Research spans myasthenia gravis, autoimmune encephalitis, ANCA-associated vasculitis, systemic lupus erythematosus, lupus nephritis, Sjögren’s syndrome, and idiopathic inflammatory myopathy, reflecting a strong therapeutic focus on immune-mediated disease.
- Myasthenia gravis
- ANCA-associated vasculitis
- Systemic lupus erythematosus
- Sjögren’s syndrome
- Idiopathic inflammatory myopathy
Work also includes myelin oligodendrocyte glycoprotein antibody-associated disease, multiple sclerosis relapse prevention, and other neuroimmune disorders.
Stroke, cerebrovascular, and critical neurological care
Clinical interests cover acute ischemic stroke, transient ischemic attack, intracerebral hemorrhage, subarachnoid hemorrhage, aneurysmal disease, and status epilepticus, with attention to urgent neurological conditions and secondary prevention.
- Acute ischemic stroke
- Transient ischemic attack
- Hemorrhagic stroke
- Subarachnoid hemorrhage
- Status epilepticus
Further activity includes vascular dementia, atrial fibrillation-related cerebrovascular risk, and neurocritical care presentations.
Headache, pain, and functional neurological symptoms
The investigator is involved in studies of migraine, chronic pain, neuropathic pain, insomnia disorder, depression, and post-traumatic stress disorder, indicating a broad interest in symptom burden and quality-of-life impairment in neurological practice.
- Migraine
- Neuropathic pain
- Insomnia disorder
- Depression
- Post-traumatic stress disorder
Research also touches on attention deficit hyperactivity disorder, anxiety, and other neuropsychiatric symptoms seen in neurological disease.
Neurogenetic and rare neurological disease
Clinical trial involvement extends to spinal muscular atrophy, Duchenne muscular dystrophy, myotonic dystrophy, spinocerebellar ataxia, Dravet syndrome, and tuberous sclerosis complex, showing engagement with inherited and rare neurological disorders.
- Spinal muscular atrophy
- Duchenne muscular dystrophy
- Myotonic dystrophy
- Spinocerebellar ataxia
- Dravet syndrome
Additional areas include rare neurodevelopmental disease, genetic movement disorders, and neuromuscular weakness syndromes.
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