Carmelo C. S.
- Country
- Italy
- Department
- U.O. Ematologia
Research Overview
- Evaluation of Safety and Pharmacokinetics of Forimtamig in Patients With Relapsed or Refractory Multiple Myeloma
- Evaluation of Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7443904 with Glofitamab in Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma Patients
- Phase I Study of ISB 2001 in Patients with Relapsed or Refractory Multiple Myeloma
Data & Insights
Has run more than one trial at 110 of 223 partner sites.
Specializations
Thoracic and solid tumor oncology
Clinical activity in non-small cell lung cancer, small cell lung cancer, head and neck squamous cell carcinoma, esophageal carcinoma, and other advanced solid tumors, with attention to targeted therapy, immunotherapy, and molecularly selected disease.
- Non-small cell lung cancer
- Head and neck squamous cell carcinoma
- Advanced solid tumors
- Small cell lung cancer
- Esophageal carcinoma
Interest extends to biomarker-driven oncology and treatment-resistant metastatic disease across multiple tumor types.
Gastrointestinal and hepatobiliary disease
Research involvement includes hepatocellular carcinoma, biliary tract cancer, cholangiocarcinoma, gastroesophageal junction adenocarcinoma, and chronic liver conditions such as non-alcoholic steatohepatitis and metabolic dysfunction-associated steatohepatitis.
- Hepatocellular carcinoma
- Biliary tract cancer
- Cholangiocarcinoma
- Non-alcoholic steatohepatitis
- Metabolic dysfunction-associated steatohepatitis
Therapeutic focus also includes primary biliary cholangitis, hepatic encephalopathy, and cirrhosis-related complications.
Hematologic malignancies and cellular therapy
Active in diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, chronic lymphocytic leukemia, multiple myeloma, and acute myeloid leukemia, with a strong emphasis on cell therapy and relapsed or refractory hematologic disease.
- Diffuse large B-cell lymphoma
- Multiple myeloma
- Acute myeloid leukemia
- Chronic lymphocytic leukemia
- CAR T-cell therapy
Research also covers myelodysplastic syndromes and high-risk lymphoma settings requiring novel immune-based strategies.
Inflammatory, autoimmune, and dermatologic disorders
Clinical interests include Crohn’s disease, ulcerative colitis, rheumatoid arthritis, systemic lupus erythematosus, atopic dermatitis, hidradenitis suppurativa, and psoriasis, reflecting broad engagement in immune-mediated disease.
- Crohn’s disease
- Ulcerative colitis
- Rheumatoid arthritis
- Atopic dermatitis
- Hidradenitis suppurativa
Additional work includes eosinophilic disorders, systemic sclerosis, and other chronic inflammatory conditions requiring targeted immunomodulation.
Cardiometabolic, renal, and rare disease therapeutics
Investigational activity spans atrial fibrillation, atherosclerotic cardiovascular disease, heart failure, venous thromboembolism, IgA nephropathy, and diabetic retinopathy, alongside rare disorders such as hemophilia and bronchiectasis.
- Atrial fibrillation
- Heart failure
- IgA nephropathy
- Hemophilia
- Diabetic retinopathy
Therapeutic interest also includes prostate cancer, ovarian cancer, and urothelial carcinoma in broader precision-medicine programs.
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