Carmel W.
- Country
- Ireland
- Department
- Cancer Clinical Trials Office
Research Overview
- Phase II Study of Acalabrutinib and Venetoclax in Patients with Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Following First-Line BTKi and BCL2 Inhibitor Therapy
- A phase 3 multicentre, randomized, prospective, open-label trial of Ibrutinib monotherapy versus fixed-duration Venetoclax plus Obinutuzumab versus fixed-duration Venetoclax plus Ibrutinib in patients with previously untreated chronic lymphocytic leukaemia (CLL) - CLL17
- Phase 3 Randomized Study of Pirtobrutinib vs. Idelalisib + Rituximab or Bendamustine + Rituximab in BTK Inhibitor-Pretreated CLL/SLL Patients
Data & Insights
Has run more than one trial at 110 of 277 partner sites.
Specializations
Haematologic Malignancies
Clinical research activity in acute myeloid leukaemia, acute lymphoblastic leukaemia, chronic lymphocytic leukaemia, small lymphocytic lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, Hodgkin lymphoma, multiple myeloma, myelodysplastic syndrome, and primary myelofibrosis.
- Leukaemia
- Lymphoma
- Myeloma
- Myelodysplastic syndromes
- Myeloproliferative neoplasms
Interest also extends to paroxysmal nocturnal haemoglobinuria, immune thrombocytopenia, and haemophilia, reflecting a broad haematology portfolio at St James's Hospital.
Breast and Gynaecologic Oncology
Trial involvement covers early breast cancer, advanced breast cancer, triple-negative breast cancer, HER2-positive breast cancer, and hormone receptor-positive, HER2-negative disease, alongside ovarian cancer, endometrial cancer, cervical cancer, gastroesophageal adenocarcinoma, and cholangiocarcinoma.
- Breast cancer
- Ovarian cancer
- Endometrial carcinoma
- Cervical cancer
- Gastrointestinal malignancies
Research themes include adjuvant, neoadjuvant, and metastatic treatment strategies, with attention to HER2-low disease and folate receptor-alpha-expressing tumours.
Thoracic and Solid Tumour Oncology
Active involvement includes non-small cell lung cancer, small-cell lung cancer, head and neck squamous cell carcinoma, oesophageal squamous cell carcinoma, melanoma, cutaneous squamous cell carcinoma, pancreatic cancer, and advanced solid tumours.
- Non-small cell lung cancer
- Small-cell lung cancer
- Head and neck cancer
- Melanoma
- Oesophageal cancer
Therapeutic interests also include perioperative and locoregional cancer care, with work spanning metastatic and resectable disease settings.
Immune-Mediated and Inflammatory Disorders
Research activity extends beyond oncology to systemic lupus erythematosus, atopic dermatitis, hidradenitis suppurativa, polymyalgia rheumatica, chronic graft-versus-host disease, and severe asthma with an eosinophilic phenotype.
- Autoimmune disease
- Dermatologic inflammation
- Rheumatologic disease
- Graft-versus-host disease
- Asthma
Additional interests include hereditary angioedema, systemic mastocytosis, and primary immune thrombocytopenia, supporting a strong presence in immune-mediated disease management.
Cardiometabolic, Infectious, and Neurologic Conditions
Clinical trial involvement also covers heart failure, cardiovascular disease, obesity, type 2 diabetes, non-alcoholic steatohepatitis, COVID-19, mpox, HIV, multiple sclerosis, and mild cognitive impairment linked to Alzheimer's disease.
- Heart failure
- Atherosclerotic disease
- Metabolic disease
- Viral infections
- Neuroinflammatory disorders
These studies reflect engagement with cardiometabolic risk reduction, infectious disease control, and neurologic and neurodegenerative care.
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