Carla G.
- Country
- Italy
- Department
- UOC di Endocrinologia e Malattie del Metabolismo
Research Overview
- Evaluation of Batoclimab Efficacy and Safety in an Open-Label Extension Study for Thyroid Eye Disease Treatment in Participants Completing IMVT-1401-3201/3202
- Intraclass Safety and Efficacy Evaluation of SGLT2 Inhibitors in Elderly Patients with Type 2 Diabetes: A Phase IV Multicenter Randomized Controlled Trial
- Evaluation of Ladarixin on Beta-Cell Function Preservation in Recent Onset Type 1 Diabetes: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 27 of 228 partner sites.
Specializations
Metabolic, Liver, and Endocrine Disorders
Clinical research activity includes obesity, type 2 diabetes, dyslipidemia, hypertriglyceridemia, atherosclerotic cardiovascular disease, and familial hypercholesterolemia, alongside liver-focused conditions such as metabolic dysfunction-associated steatotic liver disease, non-alcoholic steatohepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and alpha-1 antitrypsin deficiency-associated liver disease.
- Metabolic dysfunction-associated steatohepatitis
- Primary biliary cholangitis
- Hypertriglyceridemia
- Obesity and type 2 diabetes
- Familial hypercholesterolemia
Additional interests extend to portal hypertension, hepatic encephalopathy, post-bariatric hypoglycaemia, and thyroid eye disease, reflecting a strong focus on endocrine-metabolic complications with hepatic involvement.
Cardiovascular and Thromboembolic Disease
The investigator is involved in trials addressing atrial fibrillation, stroke, myocardial infarction, heart failure, hypertension, atherosclerosis, and variant transthyretin amyloid cardiomyopathy, with attention to risk reduction in high-risk cardiovascular populations.
- Atrial fibrillation
- Stroke
- Myocardial infarction
- Heart failure
- Atherosclerotic cardiovascular disease
Research also spans haemophilia A and haemostatic management, together with disorders linked to vascular inflammation and lipid-driven cardiovascular risk.
Autoimmune, Inflammatory, and Neuromuscular Diseases
Therapeutic interests include ulcerative colitis, Crohn's disease, psoriatic arthritis, Sjögren’s syndrome, systemic sclerosis, and myasthenia gravis, with additional activity in immune-mediated conditions such as multiple sclerosis, autoimmune encephalitis, and polymyositis.
- Ulcerative colitis
- Sjögren’s syndrome
- Myasthenia gravis
- Systemic sclerosis
- Psoriatic arthritis
Further involvement covers Graves’ disease, classic congenital adrenal hyperplasia, and other immune-mediated endocrine and neuromuscular disorders.
Oncology and Hematologic Malignancies
Clinical trial activity includes solid tumors and blood cancers such as hepatocellular carcinoma, breast cancer, non-small cell lung cancer, gastrointestinal stromal tumor, melanoma, and head and neck squamous cell carcinoma, together with hematologic malignancies including acute myeloid leukemia, chronic myeloid leukemia, multiple myeloma, and lymphoma.
- Hepatocellular carcinoma
- Multiple myeloma
- Acute myeloid leukemia
- Gastrointestinal stromal tumor
- Head and neck squamous cell carcinoma
Additional oncology interests include sarcomas, neuroendocrine tumors, cervical cancer, and chondrosarcoma.
Neurology, Respiratory, and Infectious Conditions
Research involvement extends to Alzheimer’s disease, migraine, amyotrophic lateral sclerosis, bronchiectasis, chronic obstructive pulmonary disease, and asthma, alongside infectious diseases such as HIV infection, COVID-19, mpox, and respiratory syncytial virus infection.
- Alzheimer’s disease
- Migraine
- Chronic obstructive pulmonary disease
- HIV infection
- COVID-19
Other areas include acute respiratory distress syndrome, pneumonia, and monkeypox virus disease, reflecting interest in both chronic and acute therapeutic settings.
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