Birgitta S.
- Country
- Sweden
- Department
- Department of Vascular Surgery, Karlstad Central Hospital
Research Overview
- Long-Term Safety and Efficacy of Repeated Rituximab as Adjunctive Therapy in Patients with Schizophrenia Spectrum Disorders (RITS‑LONG)
- Stroke prophylaxis with Apixaban in Chronic Kidney Disease stage 5 patients with Atrial fibrillation (SACK)
- Outcome-Adaptive Randomized Multi-Arm Study of Radium-223 Dichloride, Abiraterone Acetate, and Drug Combinations in Metastatic Prostate Cancer Patients
Data & Insights
Has run more than one trial at 28 of 89 partner sites.
Specializations
Cardiovascular and Renal Therapeutics
Investigator engages in studies targeting heart failure. He also evaluates therapies for atrial fibrillation. Advanced chronic kidney disease is a further focus.
- Apixaban anticoagulation in chronic kidney disease
- Balcinrenone/dapagliflozin for heart failure outcomes
- Spironolactone in heart failure with preserved ejection fraction
- Baxdrostat/dapagliflozin for renal protection
- SGLT2‑inhibitor strategies in hypertension
Focus includes reducing cardiovascular mortality. Preserving renal function is also a priority.
Oncology Therapeutics
Research includes colorectal cancer. He also studies prostate cancer. Early triple‑negative breast cancer is another target.
- Adjuvant immunotherapy in cutaneous melanoma
- Capecitabine addition to carboplatin in early triple‑negative breast cancer
- Biomarker‑driven trial in metastatic prostate cancer
- Aspirin adjuvant in PIK3CA‑mutated colorectal cancer
- Metformin impact on abdominal aortic aneurysm growth
Therapeutic aim is to extend survival in solid tumors.
Neuro‑Immunology and Neurology
Focus on multiple sclerosis. He investigates glioblastoma. Studies also address generalized myasthenia gravis.
- Ocrelizumab efficacy in multiple sclerosis
- Lomustine/temozolomide regimen for MGMT‑methylated glioblastoma
- Cladribine oral formulation in generalized myasthenia gravis
- Rituximab for schizophrenia spectrum disorder
- Revaccination immunity after childhood cancer therapy
Efforts aim to modulate immune pathways in central nervous system disorders.
Infectious Diseases and Vaccination
Studies address tick‑borne encephalitis. He evaluates strategies for human papillomavirus infection. Alternative treatments for extended‑spectrum β‑lactamase urinary infections are explored.
- Remdesivir assessment in tick‑borne encephalitis
- Concomitant HPV vaccination and screening program
- Oral step‑down regimen for ESBL‑producing urinary tract infections
- Varicella revaccination after cancer therapy
- Measles revaccination in post‑cancer patients
Goal is rapid pathogen control and enhanced vaccine‑induced immunity.
Metabolic and Endocrine Disorders
Investigator investigates type 1 diabetes. He also studies type 2 diabetes. Hypertension management is a further focus.
- Ixekizumab effect on insulin secretion in type 1 diabetes
- SGLT2‑inhibitor versus metformin in early type 2 diabetes
- Metformin influence on abdominal aortic aneurysm growth
- Vicadrostat plus empagliflozin in type 2 diabetes with cardiovascular disease
- Simvastatin therapy for primary sclerosing cholangitis
Glycemic control and reduction of cardiovascular risk are central objectives.
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