C. U. N.
- Country
- Denmark
- Department
- Hematology
Research Overview
- HOVON 165 CLL: A prospective randomized phase I/II trial of venetoclax treatment (26 cycles) with 6 cycles or 12 cycles of epcoritamab in patients with relapsed or refractory chronic lymphocytic leukemia or Small Lymphocytic Lymphoma. AETHER study (ABT199 + Epcoritamab THErapy for Relapsed/refractory CLL/SLL)
- Phase II Multicenter Trial of Ibrutinib and Venetoclax in Relapsed/Refractory Chronic Lymphocytic Leukemia with/without TP53 Aberrations
- HOVON 158 CLL: First line treatment with VeNEtoclaX and ibruTinib induction followed by obinutuzumab intenSificaTion Exclusively in CLL/SLL Patients not in complete remission and/or with detectable bone marrow minimal residual disease (NEXT STEP trial)
Data & Insights
Has run more than one trial at 17 of 61 partner sites.
Specializations
Myeloid Malignancies
The investigator concentrates on therapeutic advances for aggressive myeloid diseases, emphasizing disease biology and targeted interventions.
- Acute Myeloid Leukemia
- Myelodysplastic Syndrome
- Chronic Myeloid Leukemia
- Pediatric Acute Myeloid Leukemia
- Chronic Myelomonocytic Leukemia
Efforts include evaluation of novel agents and combination strategies to improve remission durability.
Lymphoid Cancers
Research activities span acute and chronic lymphoid malignancies, focusing on precision‑medicine approaches and immune‑based therapies.
- Acute Lymphoblastic Leukemia
- Chronic Lymphocytic Leukemia
- Diffuse Large B‑Cell Lymphoma
- Mantle Cell Lymphoma
- Hodgkin Lymphoma
The work targets disease‑specific biomarkers and treatment resistance mechanisms.
Hemophilia and Related Coagulopathies
Clinical investigations address hereditary bleeding disorders, aiming to optimize factor replacement and gene‑based therapies.
- Hemophilia A
- Hemophilia B
- Transfusion‑Dependent Alpha‑Thalassemia
- Non‑Transfusion‑Dependent Beta‑Thalassemia
- Clonal Cytopenia of Undetermined Significance
Studies evaluate long‑term safety and efficacy of emerging therapeutic modalities.
Hematopoietic Stem Cell Transplantation
The investigator’s portfolio includes transplantation outcomes, immune reconstitution, and post‑transplant complications.
- Allogeneic Stem Cell Transplantation
- Graft‑versus‑Host Disease
- Hematopoietic Stem Cell Mobilization
- Reduced‑Intensity Conditioning
- Post‑Transplant Infections
Focus is placed on improving survival and quality of life after transplant.
Cardiovascular & Thrombotic Issues in Hematology
Research explores vascular complications that frequently accompany hematologic disorders and their treatments.
- Atherosclerotic Cardiovascular Disease
- Thromboembolic Pulmonary Hypertension
- Myocardial Infarction
- Ischemic Stroke
- Venous Thromboembolism
Efforts aim to define risk mitigation strategies and integrate cardiovascular care into hematologic treatment pathways.
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