Bruno K.
- Country
- Germany
- Department
- Klinik für Hämatologie und Onkologie
Research Overview
- Randomized Phase 2 Study of DKN-01 Plus FOLFIRI/FOLFOX and Bevacizumab Versus FOLFIRI/FOLFOX and Bevacizumab as Second-line Treatment of Advanced Colorectal Cancer (DeFianCe)
- Efficacy of Sacituzumab Govitecan Versus Standard of Care in Metastatic Refractory Colorectal Cancer: A Phase II/III Randomized Multicenter Trial
- Preoperative FOLFOX Versus Postoperative Risk-Adapted Chemotherapy in Locally Advanced Rectal Cancer: A Phase III Randomized Trial
Data & Insights
Has run more than one trial at 62 of 141 partner sites.
Specializations
Breast Cancer and Gynecologic Oncology
Clinical activity includes HER2-negative breast cancer, triple-negative breast cancer, HR-positive disease, and HER2-positive early and advanced breast cancer, with additional involvement in ovarian cancer, endometrial cancer, fallopian tube cancer, and primary peritoneal cancer.
- Metastatic breast cancer
- Early breast cancer
- Ovarian cancer
- Endometrial cancer
The therapeutic focus extends to biomarker-defined breast malignancies and advanced gynecologic tumors requiring targeted and perioperative treatment strategies.
Hematologic Malignancies
Research interests cover acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, myelodysplastic syndromes, and diverse lymphomas, including aggressive and relapsed/refractory disease.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Diffuse large B-cell lymphoma
- Multiple myeloma
Additional work includes stem cell transplantation settings and high-risk blood cancers with unmet therapeutic need.
Thoracic, Gastrointestinal, and Genitourinary Cancers
Clinical engagement spans non-small cell lung cancer, small cell lung cancer, head and neck squamous cell carcinoma, gastric cancer, gastroesophageal junction adenocarcinoma, colorectal cancer, biliary tract cancer, pancreatic cancer, renal cell carcinoma, and urothelial carcinoma.
- Non-small cell lung cancer
- Gastric and gastroesophageal cancers
- Renal cell carcinoma
- Urothelial carcinoma
The portfolio also includes advanced solid tumors with emphasis on targeted therapy and immuno-oncology across difficult-to-treat metastatic disease.
Autoimmune, Inflammatory, and Dermatologic Diseases
Investigations include ulcerative colitis, Crohn’s disease, systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, psoriasis, atopic dermatitis, and hidradenitis suppurativa.
- Inflammatory bowel disease
- Systemic lupus erythematosus
- Psoriasis
- Atopic dermatitis
Therapeutic interest also extends to immune-mediated skin and connective tissue disorders, reflecting a strong focus on chronic inflammatory disease control.
Cardiometabolic, Renal, and Amyloid Disorders
Clinical research spans heart failure, atherosclerotic cardiovascular disease, atrial fibrillation, myocardial infarction, chronic kidney disease, IgA nephropathy, kidney transplantation, and transthyretin amyloidosis.
- Heart failure
- Chronic kidney disease
- IgA nephropathy
- Transthyretin amyloidosis
Further involvement includes cardiomyopathy, stroke prevention, and renal protection in complex multisystem disease.
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