Bastian E.
- Country
- Germany
- Department
- Clinical Oncology and Palliative Care
Research Overview
- An open-label, multicenter, Phase 1b/2a study to evaluate efficacy, safety, tolerability, and pharmacokinetics of the ATR inhibitor Tuvusertib (M1774) in combination with cemiplimab in participants with non-squamous non-small cell lung cancer that has progressed on prior anti-PD-(L)1 and platinum-based therapies (DDRiver NSCLC 322)
- Efficacy Comparison of Brigatinib Versus Second-Generation TKIs in First-Line Treatment of Locally Advanced or Metastatic ALK-Positive NSCLC
- Phase 3 Randomized Study of Adjuvant Pembrolizumab With or Without mRNA-4157 in Resectable Stage II-IIIB (N2) Non-Small Cell Lung Cancer Not Achieving pCR
Data & Insights
Has run more than one trial at 134 of 357 partner sites.
Specializations
Advanced Lung Cancer Research
The investigator specializes in treating non-small cell lung cancer (NSCLC), with particular emphasis on advanced and metastatic cases. Their research encompasses various genetic mutations including EGFR mutations, ALK-positive NSCLC, and KRAS G12C mutations.
- Stage IV NSCLC Treatment Approaches
- Genetic Mutation-Targeted Therapies
- Non-squamous NSCLC Management
Their work includes evaluation of novel combination therapies and immunotherapeutic approaches for advanced lung cancer treatment.
Gastrointestinal Oncology
The investigator focuses on treating advanced gastric cancer and gastroesophageal junction adenocarcinomas. Their expertise extends to managing cases that have progressed after initial treatment.
- Advanced Stomach Cancer Treatment
- Second-line Therapy Development
- Metastatic Adenocarcinoma Management
Research interests include innovative therapeutic combinations for patients with advanced gastrointestinal malignancies.
Advanced Solid Tumors
The investigator conducts research on locally advanced and metastatic solid tumors, including specialized work in urothelial carcinomas. Their research explores novel therapeutic combinations and immunotherapy applications.
- Immunotherapy Combinations
- Advanced Stage Treatment Strategies
- Novel Therapeutic Approaches
Their work encompasses the development of treatment strategies for various advanced-stage solid malignancies.
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