Barbara D. M.
- Country
- Belgium
- Department
- Paediatric Haemato-oncology
Research Overview
- International proof of concept therapeutic Stratification trial of Molecular Anomalies in Relapsed or Refractory HEMatological malignancies in children - Sub-protocol D
- Evaluation of Daunorubicin, Cytarabine, and Mitoxantrone Efficacy in Pediatric Acute Myeloid Leukemia Treatment: A NOPHO-DBH AML 2012 Protocol Study
- Phase I/II Evaluation of Brigatinib in Pediatric and Young Adult Patients with ALK-Positive Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumors
Data & Insights
Has run more than one trial at 20 of 63 partner sites.
Specializations
Pediatric Acute Leukemia
The investigator concentrates on Pediatric Acute Leukemia encompassing both lymphoid and myeloid lineages.
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Mixed Lineage Leukemia
- Leukemia with NPM1 mutation
- Leukemia in Down syndrome
These efforts aim to improve survival and reduce treatment‑related toxicity in children.
Pediatric Lymphoma and Hematologic Malignancies
Focused on Pediatric Lymphoma and related hematologic cancers, the work spans precursor and mature disease entities.
- Precursor B‑Lymphoblastic Lymphoma
- Precursor T‑Lymphoblastic Lymphoma
- Diffuse Large B‑Cell Lymphoma
- Burkitt lymphoma
- Hodgkin Lymphoma
The goal is to refine risk‑adapted therapies for curative outcomes.
Bone Marrow Transplantation and Cellular Therapies
Clinical investigations include Allogeneic Hematopoietic Stem Cell Transplantation and emerging cellular approaches.
- Haploidentical HSCT
- CAR‑T cell therapy
- Gene‑modified T‑cell infusions
- Conditioning regimens without total body irradiation
- Post‑transplant immune reconstitution
These studies target graft‑versus‑leukemia effects while minimizing toxicity.
Rare Pediatric Solid Tumors and Genetic Disorders
The research portfolio addresses Rare Pediatric Solid Tumors and inherited metabolic conditions.
- Neuroblastoma
- Medulloblastoma
- Rhabdomyosarcoma
- Urea Cycle Disorders
- Primary Biliary Cholangitis in children
Therapeutic strategies aim to integrate targeted agents with conventional protocols.
Immunotherapy and Targeted Therapies in Childhood Cancers
Emphasis is placed on Immunotherapy and molecularly directed treatments for pediatric malignancies.
- Checkpoint inhibitor combinations
- Bispecific antibodies
- Tyrosine kinase inhibitors
- Epigenetic modulators
- Targeted therapy for FLT3‑mutated AML
These initiatives seek to expand therapeutic options beyond cytotoxic chemotherapy.
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