Aurore I. R.
- Country
- France
- Department
- Clinique Saint Anne - Service Hematologie-Oncologie
Research Overview
Data & Insights
Has run more than one trial at 21 of 146 partner sites.
Specializations
Breast Cancer and Hormone-Driven Malignancies
The investigator is involved in clinical research across HR-positive and HER2-negative breast cancer, HER2-positive breast cancer, and triple-negative breast cancer, with attention to early, locally advanced, and metastatic disease. The portfolio also includes endocrine-based strategies and treatment adaptation in biomarker-defined breast cancer.
- Endocrine therapy and CDK4/6 inhibition
- HER2-targeted therapy
- Triple-negative breast cancer
- Biomarker-guided treatment selection
Research interest extends to treatment optimization in high-risk breast cancer and the use of molecular response markers to refine therapy choices.
Prostate Cancer and Genitourinary Oncology
The investigator is active in studies of castration-resistant prostate cancer, metastatic castration-sensitive prostate cancer, and metastatic hormone-sensitive prostate cancer, as well as molecularly selected prostate cancer populations. The research landscape also includes urothelial carcinoma and non-muscle invasive bladder cancer.
- Androgen receptor pathway strategies
- Radiation therapy combined with systemic treatment
- PARP inhibitor-based approaches
- Bladder cancer immunotherapy
Therapeutic interests include advanced prostate cancer control, oligometastatic disease management, and novel combinations in bladder cancer.
Colorectal, Gastrointestinal, and Hepatobiliary Cancers
Clinical activity covers colorectal cancer, metastatic colorectal cancer, colon carcinoma, small bowel adenocarcinoma, biliary tract carcinoma, cholangiocarcinoma, and metastatic oeso-gastric adenocarcinoma. The investigator is also involved in research on pancreatic adenocarcinoma and anal squamous cell carcinoma.
- Immunotherapy in gastrointestinal malignancies
- Targeted therapy for molecularly selected tumors
- Adjuvant and perioperative treatment
- Circulating tumor DNA-guided strategies
Research emphasis includes precision treatment in digestive cancers and therapeutic innovation for recurrent or metastatic disease.
Hematologic Malignancies and Myeloid Disorders
The investigator participates in studies of chronic lymphocytic leukemia, small lymphocytic lymphoma, follicular lymphoma, multiple myeloma, myelodysplastic syndromes, and myeloproliferative neoplasms including polycythemia vera. These activities reflect interest in both lymphoid and chronic myeloid diseases.
- B-cell malignancies
- Myeloproliferative neoplasms
- Myelodysplastic syndromes
- Antibody-based and targeted therapies
Therapeutic focus includes disease control in relapsed or high-risk hematologic conditions and newer treatment combinations for chronic blood cancers.
Melanoma, Head and Neck Cancer, and Other Solid Tumors
The investigator is also involved in research on melanoma, squamous cell carcinoma of the head and neck, oral cavity cancer, oropharyngeal cancer, laryngeal cancer, and locally advanced anal cancer. Additional activity includes ovarian cancer, endometrial cancer, bladder cancer, and non-squamous lung cancer.
- Immune checkpoint inhibition
- Antibody-drug conjugates
- Radiotherapy combinations
- Molecularly selected solid tumors
Research spans multiple tumor types with a strong emphasis on novel systemic options for advanced disease.
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