Aurelia A.
- Country
- Romania
- Department
- Medical Oncology II
Research Overview
- Phase 3 Randomized Study of Nivolumab and Ipilimumab with Chemoradiotherapy in Locally Advanced Non-Small Cell Lung Cancer
- Comparative Study of JPB898 and Nivolumab in Combination with Ipilimumab for Advanced Unresectable/Metastatic Melanoma
- Efficacy Comparison of Zanzalintinib (XL092) and Pembrolizumab Versus Pembrolizumab Monotherapy in PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Data & Insights
Has run more than one trial at 520 of 832 partner sites.
Specializations
Thoracic Oncology
Clinical research activity is strongly centered on non-small cell lung cancer, small cell lung cancer, and advanced lung malignancies, with interest in both unresectable and resectable disease settings. The portfolio also includes biomarker-defined populations such as EGFR-mutated, KRAS G12C-mutant, HER2-altered, and PD-L1-positive tumors.
- Non-small cell lung cancer
- Small cell lung cancer
- KRAS G12C-mutant lung cancer
- EGFR-mutated lung cancer
- HER2-positive thoracic malignancies
Work in this area also extends to lung cancer immunotherapy and treatment strategies for locally advanced, metastatic, and perioperative disease.
Breast and Gastrointestinal Cancers
The investigator is involved in studies of breast cancer, including HER2-positive, hormone receptor-positive, and triple-negative breast cancer, as well as high-risk early and metastatic settings. Research also covers gastric cancer and gastroesophageal junction adenocarcinoma, reflecting a broad interest in solid tumor therapeutics.
- HER2-positive breast cancer
- Triple-negative breast cancer
- Hormone receptor-positive breast cancer
- Gastric adenocarcinoma
- Gastroesophageal junction cancer
Her clinical research landscape includes interest in recurrence prevention, residual disease, and advanced disease control across these tumor types.
Melanoma, Head and Neck, and Genitourinary Oncology
Her oncology portfolio includes melanoma, head and neck squamous cell carcinoma, prostate cancer, and bladder cancer. The trial activity spans unresectable, metastatic, and resected disease, with attention to tumor control in high-risk and recurrent settings.
- Melanoma
- Head and neck squamous cell carcinoma
- Prostate cancer
- Bladder cancer
- Renal cell carcinoma
Research interests also include renal cell carcinoma and other advanced solid tumors, supporting a wide therapeutic focus in oncologic care.
Hematologic Malignancies
Clinical trial involvement extends to a broad spectrum of lymphoid and myeloid malignancies, including aggressive and indolent lymphoma subtypes, chronic lymphocytic leukemia, myelodysplastic syndrome, and acute myeloid leukemia. The research scope reflects interest in relapsed, refractory, and newly diagnosed hematologic cancers.
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Chronic lymphocytic leukemia
- Myelodysplastic syndrome
- Acute myeloid leukemia
Her participation also includes rarer entities such as mantle cell lymphoma, marginal zone lymphoma, and Waldenström macroglobulinemia.
Autoimmune and Inflammatory Diseases
Beyond oncology, the investigator is engaged in therapeutic research for psoriatic arthritis, systemic lupus erythematosus, rheumatoid arthritis, Sjögren's disease, systemic sclerosis, and ulcerative colitis. This area also includes studies in plaque psoriasis, osteoarthritis of the knee, and migraine.
- Psoriatic arthritis
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Systemic sclerosis
- Ulcerative colitis
Her research profile also includes heart failure and cardiometabolic disease, indicating involvement in therapeutic areas beyond cancer and immune-mediated disorders.
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