A T.
- Country
- The Netherlands
- Department
- Rheumatology
Research Overview
- Evaluation of Tofacitinib Efficacy in Psoriatic Arthritis: A Stratification Study Using Clinical, Transcriptomic, Metabolomic, and Proteomic Data
- Evaluation of Secukinumab for Maintenance of Remission in Non-Radiographic Axial Spondyloarthritis: A Randomized, Double-Blind, Placebo-Controlled Study
- Evaluation of Disease Activity-Guided Dose Reduction of Janus Kinase Inhibitors Filgotinib, Tofacitinib, Upadacitinib, and Baricitinib in Inflammatory Rheumatic Diseases
Data & Insights
Has run more than one trial at 4 of 69 partner sites.
Specializations
Rheumatology and systemic autoimmune disease
Clinical research activity in rheumatology includes inflammatory and immune-mediated disorders, with a strong focus on chronic diseases that affect joints, connective tissue, and systemic organs. The investigator is involved in studies addressing psoriatic arthritis, non-radiographic axial spondyloarthritis, systemic lupus erythematosus, and Sjögren's disease.
- Psoriatic arthritis
- Non-radiographic axial spondyloarthritis
- Systemic lupus erythematosus
- Sjögren's disease
Work in this area also extends to fibromyalgia, fatigue, and inflammatory bowel disease-associated immune overlap, reflecting interest in complex inflammatory syndromes managed through the Department of Reumatologie at University Hospital Maastricht.
Cardiovascular medicine and vascular risk
The investigator is engaged in clinical research on cardiovascular disease, with attention to prevention and treatment across heart failure, hypertension, atrial fibrillation, and acute coronary syndrome. The portfolio also includes peripheral arterial disease and stroke prevention.
- Heart failure
- Hypertension
- Atrial fibrillation
- Acute coronary syndrome
Additional activity spans hypertrophic cardiomyopathy, subclinical heart failure, and ischemic stroke, highlighting interest in cardiovascular risk reduction and organ protection.
Oncology and hematologic malignancies
Research involvement covers a broad oncologic landscape, with particular emphasis on non-small cell lung cancer, breast cancer, colorectal cancer, and pancreatic cancer. The investigator also contributes to studies in advanced solid tumors and site-specific malignancies.
- Non-small cell lung cancer
- Breast cancer
- Colorectal cancer
- Pancreatic cancer
Hematologic interests include lymphoma, multiple myeloma, acute myeloid leukemia, and chronic lymphocytic leukemia, alongside research in melanoma, endometrial cancer, and urothelial carcinoma.
Gastroenterology, hepatobiliary, and pancreatic disease
The investigator is active in clinical studies involving inflammatory bowel disease, including Crohn's disease and ulcerative colitis, as well as upper and lower gastrointestinal disorders. Research also includes cholangiocarcinoma, hepatocellular carcinoma, and pancreatitis.
- Crohn's disease
- Ulcerative colitis
- Cholangiocarcinoma
- Pancreatitis
Further therapeutic interest is seen in gastroenteropancreatic neuroendocrine tumors, esophageal cancer, and rectal cancer, reflecting engagement with digestive tract oncology and inflammatory gastrointestinal disease.
Rare disease, renal, and immune-mediated conditions
The investigator also participates in studies of amyloidosis, transthyretin amyloidosis, immunoglobulin A nephropathy, and lupus nephritis. This area includes attention to kidney disease and immune-mediated organ involvement.
- Transthyretin amyloidosis
- Immunoglobulin A nephropathy
- Lupus nephritis
- Kidney disease
Related interests extend to primary immunodeficiency diseases, systemic mastocytosis, and chronic graft-versus-host disease, indicating involvement in uncommon immune and multisystem disorders.
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