Arrigo Francesco Giuseppe C.
- Country
- Italy
- Department
- #3661:U.O. di Medicina Interna
Research Overview
- Effect of Olpasiran on Major Cardiovascular Events in Patients with Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a): A Randomized, Placebo-Controlled Study
- A Randomized, Placebo‑Controlled Trial of Zenagamtide (NNC0487‑0111) in Obese Patients with HFpEF or HFmrEF to Reduce CV Death and HF Hospitalization
- Effect of Muvalaplin on Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) and Atherosclerotic Cardiovascular Disease: A Phase 3 Randomized Trial
Data & Insights
Has run more than one trial at 784 of 1468 partner sites.
Specializations
Cardiovascular disease and metabolic risk
Clinical work includes atherosclerotic cardiovascular disease, arterial hypertension, atrial fibrillation, heart failure, calcific aortic valve stenosis, pulmonary hypertension, and dyslipidemia, with additional interest in obesity, type 2 diabetes mellitus, and hypertriglyceridemia.
- Resistant hypertension
- Chronic heart failure
- Transthyretin amyloid cardiomyopathy
- Cardiometabolic syndrome
Research activity also extends to lipoprotein(a)-related risk, recurrent pericarditis, and venous thromboembolism prevention.
Hematologic malignancies and cellular therapy
The investigator is involved across a broad spectrum of blood cancers, including acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, myelofibrosis, multiple myeloma, and non-Hodgkin lymphoma.
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Marginal zone lymphoma
- CAR T-cell therapy
Clinical interests also include gene-modified T cells, graft-versus-host disease, and transplant-associated complications.
Solid tumors and genitourinary oncology
Research spans breast cancer, ovarian cancer, endometrial cancer, prostate cancer, urothelial carcinoma, renal cell carcinoma, non-small cell lung cancer, and hepatocellular carcinoma.
- Triple-negative breast cancer
- Metastatic castration-resistant prostate cancer
- Advanced urothelial cancer
- Gastrointestinal stromal tumor
Additional involvement covers head and neck squamous cell carcinoma, cholangiocarcinoma, and pancreatic ductal adenocarcinoma.
Autoimmune, inflammatory, and dermatologic disease
The investigator is active in ulcerative colitis, Crohn’s disease, eosinophilic esophagitis, atopic dermatitis, psoriasis, vitiligo, and lupus-related disorders.
- Immune thrombocytopenia
- Juvenile idiopathic arthritis
- Primary immunoglobulin A nephropathy
- Chronic spontaneous urticaria
Therapeutic interests also include autoimmune glomerular disease, bullous pemphigoid, and alopecia areata.
Renal, hepatic, and rare disease therapeutics
Clinical research includes chronic kidney disease, IgA nephropathy, membranous nephropathy, complement-mediated kidney disease, Fabry disease, and primary hyperoxaluria.
- Alcohol-related liver disease
- Nonalcoholic steatohepatitis
- Cirrhosis
- Primary biliary cholangitis
Work also touches hepatic encephalopathy, kidney transplant rejection, and amyloidosis.
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