Arend A.
- Country
- The Netherlands
- Department
- Surgery
Research Overview
- Phase 2 Randomized Study of Radium-224 Adsorbed in Calcium Carbonate Microparticles for Peritoneal Carcinomatosis from Colorectal Carcinoma Post-CRS and HIPEC
- Randomized Controlled Trial of Induction Chemotherapy with Irinotecan, Folinic Acid, and Oxaliplatin Followed by Chemoradiotherapy for Locally Recurrent Rectal Cancer
- Evaluation of Induction Chemotherapy with FOLFOXIRI in High-Risk Locally Advanced Rectal Cancer: A Study on Pathological and Clinical Response Rates
Data & Insights
Has run more than one trial at 18 of 42 partner sites.
Specializations
Thoracic Oncology
Non-small cell lung cancer, small cell lung cancer, and other thoracic malignancies form a major part of this investigator’s clinical research focus, with attention to advanced, metastatic, and biomarker-defined disease.
- Advanced non-small cell lung cancer
- EGFR-mutated and ALK-rearranged lung cancer
- Small cell lung cancer
- Pleural mesothelioma
Research activity also extends to treatment strategies for lung cancer with KRAS G12C, HER2, ROS1, and RET alterations, reflecting a strong interest in molecularly guided therapy.
Gastrointestinal Cancer
The investigator is involved in clinical studies across the gastrointestinal tract, including upper and lower GI cancers, with emphasis on advanced and resectable disease settings.
- Colorectal cancer
- Gastric and gastroesophageal junction adenocarcinoma
- Esophageal squamous cell carcinoma
- Pancreatic and biliary tract cancer
Additional interest includes neuroendocrine tumors, gastrointestinal stromal tumor, and peritoneal metastases, supporting a broad surgical-oncology profile in digestive cancers.
Genitourinary and Male Cancers
Clinical research in urothelial carcinoma, renal cell carcinoma, and prostate cancer is a prominent part of the investigator’s portfolio, spanning localized, advanced, and metastatic disease.
- Bladder cancer and muscle-invasive bladder cancer
- Renal cell carcinoma
- Metastatic castration-resistant prostate cancer
- High-risk localized prostate cancer
Work also includes oligometastatic prostate cancer and non-muscle-invasive bladder cancer, highlighting interest in disease control and organ-preserving treatment approaches.
Breast and Gynecologic Oncology
The investigator contributes to studies in breast cancer and gynecologic malignancies, with participation across hormone-driven, HER2-driven, and aggressive tumor subtypes.
- Triple-negative breast cancer
- HER2-positive and HER2-low breast cancer
- Endometrial carcinoma
- Cervical, vulvar, and ovarian cancer
Research interests also include fertility-sparing treatment in cervical cancer and management of advanced ovarian cancer, reflecting a focus on both oncologic control and preservation of function.
Melanoma, Sarcoma, and Rare Solid Tumors
The investigator is also active in trials involving melanoma, soft tissue sarcoma, and other uncommon solid tumors, particularly in advanced or refractory disease.
- Cutaneous and metastatic melanoma
- Leiomyosarcoma and liposarcoma
- Desmoid tumors
- Advanced solid tumors with actionable biomarkers
Additional areas include head and neck squamous cell carcinoma and rare germ cell tumors, supporting a wide therapeutic scope in difficult-to-treat malignancies.
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