Antonio D. P.
- Country
- Italy
- Department
- UO di Nefrologia e Dialisi
Research Overview
- Evaluation of Peritoneal Ultrafiltration with PolyCore in Patients with Congestive Heart Failure and Cardio Renal Syndrome: Impact on Mortality and Condition Worsening
- Evaluation of Corticosteroids, Dapagliflozin, and RASBs on Proteinuria in IgA Nephropathy Patients with Active and Chronic Renal Lesions
- A Phase 2b/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Combined Dose-Finding and Cardiovascular Outcome Study to Investigate the Efficacy and Safety of CSL300 (Clazakizumab) in Subjects with End Stage Kidney Disease Undergoing Dialysis
Data & Insights
Has run more than one trial at 20 of 221 partner sites.
Specializations
Nephrology and Dialysis
Antonio De Pascalis is involved in studies centred on nephrology, dialysis, and kidney-related complications, with particular attention to idiopathic IgA nephropathy, end-stage kidney disease, and atherosclerotic cardiovascular disease in patients with renal impairment. His research scope also includes supportive strategies for chronic kidney conditions and fluid management.
- Idiopathic IgA nephropathy
- End-stage kidney disease
- Atherosclerotic cardiovascular disease in renal disease
- Peritoneal ultrafiltration
His clinical activity at Ospedale Vito Fazzi Lecce reflects an interest in therapies that address renal inflammation, proteinuria, and cardiovascular risk in complex kidney disease.
Haematologic Malignancies
His trial portfolio shows strong involvement in acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, and myelodysplastic syndromes, including relapsed and high-risk disease settings. He is also engaged in research on lymphoma and multiple myeloma, with emphasis on targeted and immune-based treatment options.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Chronic lymphocytic leukemia
- Myelodysplastic syndromes
- Lymphoma and multiple myeloma
His research interests include MRD-guided treatment, allogeneic stem cell transplantation, and novel approaches for refractory blood cancers.
Solid Tumours in Oncology
Antonio De Pascalis is active in studies of non-small cell lung cancer, breast cancer, ovarian cancer, renal cell carcinoma, gastric cancer, and colorectal cancer. His therapeutic focus extends to advanced and metastatic disease, where targeted treatment and immunotherapy are central themes.
- Non-small cell lung cancer
- Breast cancer
- Ovarian cancer
- Renal cell carcinoma
- Gastric and colorectal cancer
His work also includes prostate cancer, cervical cancer, and pancreatic cancer, with interest in biomarker-driven and precision oncology strategies.
Cardiovascular and Thromboembolic Disease
His research landscape includes acute ischemic stroke, transient ischemic attack, myocardial infarction, heart failure, low-cardiac output syndrome, and recurrent pericarditis. These studies reflect a therapeutic interest in vascular protection, cardiac support, and prevention of recurrent ischemic events.
- Acute ischemic stroke and transient ischemic attack
- Myocardial infarction
- Heart failure
- Low-cardiac output syndrome
- Recurrent pericarditis
His involvement also reaches transthyretin amyloid cardiomyopathy and antithrombotic strategies for secondary prevention.
Autoimmune and Inflammatory Disorders
Antonio De Pascalis also contributes to studies in juvenile idiopathic arthritis, including polyarticular and treatment-remission settings, as well as colchicine-resistant recurrent pericarditis. His therapeutic interests cover anti-TNF treatment strategies, biologic switching, and inflammation control in paediatric and chronic immune-mediated disease.
- Juvenile idiopathic arthritis
- Colchicine-resistant recurrent pericarditis
- Anti-TNF treatment strategies
- Biologic therapy switching
His research activity includes disease control, flare prevention, and treatment optimisation in paediatric rheumatology.
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