Anthonie V. D. W.
- Country
- The Netherlands
- Department
- Department of pulmonology
Research Overview
- Comparison of Sotorasib Plus Combination Therapy Versus Pembrolizumab Plus Combination Therapy in PD-L1 Negative KRAS p.G12C Positive Advanced Non-Squamous NSCLC
- Phase 3 Multicenter Trial Comparing Repotrectinib and Crizotinib in TKI-naïve ROS1-positive Advanced Non-Small Cell Lung Cancer
- Evaluation of Intracranial Efficacy of JDQ443 in Patients with KRAS G12C-Mutant Non-Small Cell Lung Cancer and Brain Metastases: A Phase II Study
Data & Insights
Has run more than one trial at 116 of 282 partner sites.
Specializations
Targeted Lung Cancer Therapy
The investigator specializes in researching advanced treatment approaches for non-small cell lung cancer (NSCLC), with particular focus on targeted therapies for specific genetic mutations including EGFR, ALK, ROS1, and KRAS G12C.
- EGFR-mutated NSCLC treatment optimization
- ALK-positive NSCLC therapeutic management
- ROS1-positive tumor interventions
Their work encompasses innovative dosing strategies and therapeutic drug monitoring to enhance treatment efficacy.
Novel Drug Development
Focuses on evaluating emerging therapeutic agents for advanced solid tumors, particularly investigating novel compounds targeting specific molecular pathways and genetic alterations.
- First-in-human studies of new compounds
- Combination therapy approaches
- Drug resistance mechanisms
Their research includes assessment of novel targeted therapies and immunotherapy combinations.
Precision Medicine Applications
Specializes in developing personalized treatment strategies for patients with specific genetic mutations and exploring innovative approaches to brain metastases management.
- Biomarker-driven treatment selection
- Pharmacokinetic optimization
- CNS disease control strategies
Focuses on improving treatment outcomes through personalized dosing and molecular targeting.
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