Anne-Els V. D. L.
- Country
- The Netherlands
- Department
- D10-539: Nephrology
Research Overview
- Evaluation of Obinutuzumab on Anti-PLA2R Antibody Kinetics in Primary Membranous Nephropathy Patients: A Pilot Study
- A Phase 2b/3 Adaptive, Randomized, Active controlled Study Evaluating the Efficacy, Safety, and Tolerability of Povetacicept Versus Calcineurin Inhibitor in the Treatment of Primary Membranous Nephropathy
Data & Insights
Has run more than one trial at 1 of 21 partner sites.
Specializations
Inflammatory Bowel Disease and Gastrointestinal Immunology
The investigator is involved in clinical research on Crohn’s disease, ulcerative colitis, and related inflammatory bowel disease conditions, with interest in therapies aimed at controlling intestinal inflammation and improving disease activity in both adult and paediatric populations.
- Crohn’s disease
- Ulcerative colitis
- Inflammatory bowel disease
Research activity also extends to primary biliary cholangitis and cholestatic pruritus, reflecting a therapeutic focus on immune-mediated digestive and hepatobiliary disorders.
Kidney Disease and Proteinuric Glomerular Disorders
Clinical trial involvement includes chronic kidney disease and a range of glomerular diseases, particularly conditions marked by proteinuria and immune-mediated renal injury.
- IgA nephropathy
- Focal segmental glomerulosclerosis
- Alport syndrome
The investigator is also engaged in studies relevant to primary membranous nephropathy, complement-mediated kidney disease, and kidney transplant care.
Cardiovascular Disease and Thrombotic Risk
The research portfolio includes atherosclerotic cardiovascular disease, myocardial infarction, heart failure, and hypertension, with attention to prevention and treatment strategies across high-risk cardiovascular populations.
- Acute myocardial infarction
- Established cardiovascular disease
- Resistant hypertension
Additional interest is seen in aortic valve disease, pulmonary embolism, and antithrombotic therapy, supporting work in cardiovascular risk reduction and procedural aftercare.
Hematologic Malignancies and Oncology
The investigator participates in clinical studies across hematologic cancers and solid tumors, including disease areas where targeted and immune-based treatments are being explored.
- Multiple myeloma
- Acute myeloid leukemia
- Non-Hodgkin lymphoma
Oncology interests also include colorectal cancer, urothelial carcinoma, melanoma, breast cancer, and prostate cancer, with a therapeutic emphasis on advanced and recurrent disease settings.
Autoimmune, Genetic, and Rare Diseases
Research involvement spans rheumatoid arthritis, systemic sclerosis, myotonic dystrophy, facioscapulohumeral muscular dystrophy, and other uncommon inherited or immune-mediated disorders.
- Rheumatoid arthritis
- Systemic sclerosis
- Myotonic dystrophy type 1
Additional therapeutic areas include retinal dystrophies, hemophilia A, and primary immunodeficiency, indicating engagement with precision-oriented treatments for rare chronic conditions.
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