Anna M. K.
- Country
- Poland
- Department
- Klinika Kardiologii
Research Overview
- Efficacy of Valsartan in Reducing Aortic Root Dilatation in Pediatric and Young Adult Patients with Marfan-Type Heritable Thoracic Aortic Diseases
- (21466) A multicenter, randomized, double-blind, placebo-controlled, Phase 3 study to investigate the efficacy, safety, and PK/ PD of finerenone, in addition to standard-of-care, in pediatric patients, 6 months to < 18 years of age, with heart failure (HF) and left ventricular systolic dysfunction (LVSD)
- (21467) A Phase 3, single-arm, open-label extension study to evaluate the safety of finerenone in addition to standard of care, in pediatric heart failure patients, from birth to 18 years of age, with left ventricular systolic dysfunction (LVSD)
Data & Insights
Has run more than one trial at 43 of 46 partner sites.
Specializations
Cardiovascular medicine and lipid disorders
Clinical research activity is centered on atherosclerotic cardiovascular disease, hyperlipidaemia, familial hypercholesterolaemia, hypertriglyceridemia, and elevated lipoprotein(a), with additional interest in heart failure and cardiomyopathy.
- Major adverse cardiovascular events
- LDL-C lowering
- Triglyceride-related disorders
- Heart failure and structural heart disease
The therapeutic profile also includes hypertrophic cardiomyopathy, transthyretin amyloidosis, and prevention-focused care in patients with high cardiovascular risk.
Breast cancer and other solid tumors
Oncology involvement spans breast cancer, including HER2-positive, HER2-negative, triple-negative breast cancer, and ER-positive disease, together with broader work in non-small cell lung cancer, small cell lung cancer, and other advanced solid tumors.
- Advanced breast cancer
- Non-small cell lung cancer
- Small cell lung cancer
- Metastatic solid tumors
Research interests also extend to endometrial cancer, ovarian cancer, and colorectal cancer, reflecting a strong focus on modern systemic cancer therapy.
Inflammatory and autoimmune diseases
Clinical trial activity includes ulcerative colitis, Crohn's disease, and related inflammatory bowel disease conditions, with additional involvement in multiple sclerosis and myasthenia gravis.
- Ulcerative colitis
- Crohn's disease
- Multiple sclerosis
- Myasthenia gravis
Other areas of interest include immune-mediated gastrointestinal disease and pediatric neuroinflammatory disorders.
Pediatric endocrinology and growth disorders
Research activity covers growth hormone deficiency, idiopathic short stature, small for gestational age, Turner syndrome, and Noonan syndrome, alongside hypoparathyroidism and hypophosphatasia.
- Growth disorders
- Short stature
- Hypoparathyroidism
- Bone and mineral disorders
The portfolio also includes osteogenesis imperfecta and other pediatric conditions requiring long-term endocrine and skeletal management.
Rare genetic, renal, and neurologic conditions
Additional trial involvement includes Marfan syndrome and related heritable thoracic aortic disease, chronic kidney disease with proteinuria, nephrotic syndrome, and selected genetic neurodevelopmental disorders.
- Heritable aortic disease
- Chronic kidney disease
- Neurodevelopmental disorders
- Pediatric epilepsy
Interest also extends to spinal muscular atrophy, tuberous sclerosis complex, and other rare inherited diseases with multisystem involvement.
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