Aniello M.
- Country
- Italy
- Department
- Padiatric Department
Research Overview
Data & Insights
Has run more than one trial at 0 of 22 partner sites.
Specializations
Renal Disease and Nephrology
Focus on targeted therapies for proteinuria in kidney disorders, integrating corticosteroid strategies with renin‑angiotensin system modulation and SGLT2 inhibition.
- Proteinuria reduction with early corticosteroid therapy
- Combination of SGLT2 inhibitors and RAS blockers
- Kidney biopsy‑guided treatment selection
Collaboration at Presidio Ospedaliero Antonio Perrino supports multidisciplinary renal research.
Hormone‑Receptor Positive Breast Cancer
Investigation of novel endocrine and PI3K pathway inhibitors to extend progression‑free survival after prior CDK4/6 and aromatase blockade.
- Alpelisib plus fulvestrant efficacy
- PI3K‑targeted therapy in advanced disease
- Post‑CDK4/6 treatment sequencing
Research conducted within the pediatric department reflects translational interest in endocrine‑driven malignancies.
Urothelial Cancer
Evaluation of maintenance strategies employing PARP inhibition to delay progression following platinum‑based chemotherapy.
- niraparib as maintenance therapy
- Post‑platinum disease control
- Progression‑free survival optimization
The single clinical site enables focused enrollment of advanced urothelial patients.
Respiratory Medicine – Uncontrolled Asthma
Comparative assessment of triple‑therapy inhaled formulations to improve forced expiratory volume in adolescents with persistent asthma.
- Triple bronchodilator/inhaled corticosteroid combo
- Forced expiratory volume improvement
- Long‑term asthma control
Pediatric setting facilitates recruitment of adolescent participants.
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