Angela S. G.
- Country
- Spain
- Department
- Thoracic Oncology
Research Overview
- ONC201 for the Treatment of Newly Diagnosed H3 K27M-mutant Diffuse Glioma Following Completion of Radiotherapy: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study (The ACTION Study)
- Phase 3 Trial of N-803, Tislelizumab, and Docetaxel vs. Docetaxel in Advanced/Metastatic NSCLC with Acquired Resistance to Immune Checkpoint Inhibitors
- Phase 3 Randomized Study of Niraparib Tosilate Monohydrate vs. Temozolomide in Newly Diagnosed MGMT Unmethylated Glioblastoma
Data & Insights
Has run more than one trial at 25 of 141 partner sites.
Specializations
Neuro-Oncology
The investigator specializes in treating aggressive brain tumors, with particular focus on glioblastoma and diffuse glioma. Their research encompasses innovative therapeutic approaches for patients with specific genetic and molecular markers.
- MGMT unmethylated glioblastoma management
- H3 K27M-mutant diffuse glioma treatment
- Post-radiotherapy interventions
Their therapeutic interests extend to developing targeted treatments for molecularly defined brain tumors, particularly those with specific genetic mutations.
Molecular Targeted Therapies
The investigator focuses on developing personalized treatment approaches based on molecular markers, including MGMT methylation status and H3 K27M mutations. Their work involves evaluating novel therapeutic agents for specific patient populations.
- Novel therapeutic compounds
- Biomarker-driven treatment selection
- Targeted therapy optimization
Their research emphasizes the importance of molecular profiling in guiding treatment decisions for brain tumor patients.
Treatment Innovation
The investigator explores alternative treatment options to standard chemotherapy, investigating novel agents such as niraparib and ONC201. Their work aims to improve survival outcomes in patients with difficult-to-treat brain tumors.
- Alternative treatment pathways
- Survival outcome optimization
- Therapeutic resistance management
Their research focuses on developing more effective treatments for patients who may not respond optimally to conventional therapies.
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