Ananu-Florentin V.
- Country
- Romania
- Department
- NA
Research Overview
- A phase III, randomised, double-blind, multicentre study comparing the efficacy, safety, and immunogenicity of proposed tocilizumab biosimilar (DRL_Tocilizumab) with tocilizumab reference product (RoActemra®) administered by the subcutaneous route as an add-on to methotrexate in the treatment of patients with moderate to severe rheumatoid arthritis
- Phase 3 Study on the Efficacy and Safety of Cenerimod in Adults with Moderate-to-Severe Systemic Lupus Erythematosus
- Randomized, Double-Blind, Multicenter Study on Efficacy, Safety, and Immunogenicity of Abatacept Biosimilar DRL_AB vs. Abatacept with Methotrexate in Rheumatoid Arthritis
Data & Insights
Has run more than one trial at 93 of 263 partner sites.
Specializations
Cardiovascular disease and heart failure
Clinical research activity includes prevention and treatment strategies for atherosclerotic cardiovascular disease, acute myocardial infarction, atrial fibrillation, and advanced heart failure, with attention to both heart failure with reduced ejection fraction and heart failure with preserved ejection fraction.
- Acute coronary syndromes and recurrent myocardial infarction
- Thromboembolic risk and anticoagulation-related complications
- Cardiometabolic risk reduction and lipid-related disorders
- Pulmonary hypertension linked to cardiac disease
The therapeutic focus also extends to cardiovascular prevention in patients with hypertension, elevated lipoprotein(a), and high overall cardiovascular risk.
Inflammatory and autoimmune diseases
Research involvement covers chronic immune-mediated disorders such as rheumatoid arthritis, psoriatic arthritis, plaque psoriasis, systemic lupus erythematosus, and Crohn’s disease and ulcerative colitis.
- Rheumatoid arthritis and biosimilar treatment options
- Psoriatic arthritis and plaque psoriasis
- Systemic lupus erythematosus
- Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis
These activities reflect a therapeutic interest in long-term control of immune-driven inflammation and expansion of treatment choices in chronic autoimmune disease.
Metabolic, obesity, and kidney disorders
The investigator is engaged in studies addressing obesity, overweight, chronic kidney disease, and the overlap between cardiometabolic disease and renal outcomes.
- Weight management and obesity-related complications
- Kidney protection in high-risk cardiometabolic populations
- Hypertension with renal and cardiovascular burden
- Metabolic disease with concurrent heart failure risk
Therapeutic interests also include agents targeting glycaemic and cardiorenal risk, especially in patients with overlapping metabolic and cardiovascular disease.
Infectious disease and perioperative infection prevention
Clinical trial involvement includes management of complicated urinary tract infection, acute pyelonephritis, chronic hepatitis D infection, and prevention of postoperative infectious complications.
- Urinary tract and renal infections
- Viral liver disease
- Surgical site infection prevention
- Women’s infectious conditions such as bacterial vaginosis and vulvovaginal candidiasis
This area also includes therapeutic interest in infection control for patients receiving anticoagulant treatment during dental procedures.
Rare disease, urology, and hematologic conditions
Additional research activity spans achondroplasia, nonmuscle invasive bladder cancer, urinary incontinence, and congenital antithrombin deficiency, alongside selected cardiovascular and bleeding-risk indications.
- Growth disorder therapy in achondroplasia
- Nonmuscle invasive bladder cancer
- Urinary incontinence and genitourinary health
- Inherited thrombophilia and bleeding prevention
These studies reflect involvement in therapeutic areas where targeted treatment options are being developed for uncommon or highly specific clinical conditions.
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