Ambrogio O.
- Country
- Italy
- Department
- UOSD Malattie Infettive Croniche Intestinali
Research Overview
- A randomized, double-blind, placebo controlled, dose finding study to assess the efficacy and safety of SAR443122 in adult patients with moderate to severe ulcerative colitis
- Phase II Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vixarelimab in Patients with Moderate to Severe Ulcerative Colitis
- A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Tulisokibart in Participants with Moderately to Severely Active Ulcerative Colitis
Data & Insights
Has run more than one trial at 310 of 487 partner sites.
Specializations
Hematologic Malignancies
Clinical research activity is centered on lymphoid and myeloid cancers, with interest in both newly diagnosed and relapsed or refractory disease. The therapeutic scope includes acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and Hodgkin lymphoma.
- Acute leukemia
- B-cell non-Hodgkin lymphoma
- Chronic lymphocytic leukemia
- Multiple myeloma
- Peripheral T-cell lymphoma
The portfolio also extends to transplant-related hematology and disease settings requiring novel immunotherapy, targeted therapy, and combination regimens.
Inflammatory Bowel Disease and Gastroenterology
Another major area of interest is gastrointestinal inflammatory disease, especially Crohn’s disease and ulcerative colitis. The investigator is involved in trials addressing active disease control, symptom improvement, and maintenance of remission across chronic intestinal inflammation.
- Crohn’s disease
- Ulcerative colitis
- Eosinophilic gastritis
- Eosinophilic duodenitis
- Endoscopic response
This work reflects sustained involvement in immune-mediated gastrointestinal disorders and therapies aimed at controlling mucosal inflammation.
Hereditary Angioedema and Complement-Mediated Disorders
There is a clear therapeutic focus on hereditary angioedema, including both acute treatment and prophylaxis. The research landscape includes patients with C1-inhibitor deficiency and recurrent angioedema attacks requiring targeted symptom control.
- Hereditary angioedema
- Angioedema attack prevention
- On-demand treatment
- Long-term prophylaxis
- C1-inhibitor deficiency
The investigator’s activity in this field is aligned with advancing bradykinin-mediated disease management.
Solid Tumors and Oncologic Precision Medicine
Clinical trial involvement also includes selected solid tumors, with attention to biomarker-defined and advanced disease settings. This includes non-small cell lung cancer, small cell lung cancer, biliary tract cancers, metastatic colorectal cancer, and myocardial infarction-related cardiovascular research linked to treatment innovation.
- Non-small cell lung cancer
- Small cell lung cancer
- Biliary tract cancer
- Metastatic colorectal cancer
- Precision oncology
Research interests in this domain include molecularly selected treatment strategies and combinations designed for difficult-to-treat advanced malignancies.
Hematopoietic Transplantation and Immune Complications
The investigator is active in complications related to hematopoietic stem cell transplantation, including graft-versus-host disease and transplant-associated thrombotic microangiopathy. Related interests include post-transplant immune dysfunction and supportive hematology.
- Graft-versus-host disease
- Transplant-associated thrombotic microangiopathy
- Allogeneic stem cell transplantation
- Post-transplant complications
- Supportive hematology
This area connects transplant medicine with immune-mediated blood disorders and post-treatment complication management.
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