Amandine G. L.
- Country
- France
- Department
- Médecine physique et de réadaptation
Research Overview
Data & Insights
Has run more than one trial at 0 of 10 partner sites.
Specializations
Respiratory and Sleep Medicine
Investigator focuses on chronic airway diseases and sleep‑related breathing disorders.
- Obstructive sleep apnea in overweight and obese adults
- Severe asthma with eosinophilic inflammation
- Chronic obstructive pulmonary disease
Research aims to enhance respiratory function and reduce disease‑related morbidity.
Oncology – Advanced Solid Tumors
Investigator is involved in clinical studies of a broad spectrum of malignant neoplasms.
- Non‑small cell lung cancer (including EGFR‑mutated and KRAS‑mutated subtypes)
- Breast cancer (hormone‑receptor positive and triple‑negative)
- Colorectal cancer and microsatellite‑instability high tumors
- Urothelial carcinoma
- Mesothelioma
Emphasis is placed on therapeutic options for refractory and metastatic disease.
Hematology and Transplant Immunology
Investigator participates in studies addressing blood cancers and post‑transplant complications.
- Acute graft‑versus‑host disease affecting gastrointestinal tract
- Acute lymphoblastic leukemia in adults
- Acute myeloid leukemia with IDH1/2 mutations
- Multiple myeloma in relapsed or refractory settings
- Hemophilia A and B with inhibitors
Work includes optimizing immunosuppressive strategies and novel cellular therapies.
Neurology and Neurorehabilitation
Investigator’s interests cover acute brain injury and chronic neurodegenerative disorders.
- Acute ischemic stroke and high‑risk transient ischemic attack
- Multiple sclerosis (relapsing and progressive forms)
- Amyotrophic lateral sclerosis
- Epilepsy including focal onset seizures
- Traumatic brain injury
Goals include improving functional recovery and disease‑modifying outcomes.
Metabolic and Cardiovascular Diseases
Investigator engages in research targeting metabolic risk factors and cardiovascular events.
- Obesity and overweight without type 2 diabetes
- Type 2 diabetes remission after bariatric interventions
- Atherosclerotic cardiovascular disease including elevated lipoprotein (a)
- Atrial fibrillation with chronic kidney disease
- Hypertension uncontrolled in chronic kidney disease
Research emphasizes risk reduction and long‑term cardiovascular health.
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