Amanda T.
- Country
- Germany
- Department
- Medizinische Klinik und Poliklinik V, Standort Innenstadt
Research Overview
- A Randomized Phase 3 Study of Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab, with or without Platinum Chemotherapy, in Subjects with No Prior Therapy for Advanced or Metastatic PD-L1 TPS<50% Non-squamous Non-small Cell Lung Cancer without Actionable Genomic Alterations (TROPION-Lung07)
- Efficacy of Cobolimab, Dostarlimab, and Docetaxel in Advanced Non-Small Cell Lung Cancer Post Anti-PD(L)1 Therapy and Chemotherapy
- Efficacy and Safety of PF-08634404 Plus Combination Therapy Versus Pembrolizumab Plus Combination Therapy in Adults With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Data & Insights
Has run more than one trial at 333 of 576 partner sites.
Specializations
Pulmonology and Thoracic Oncology
Clinical research in non-small cell lung cancer, small cell lung cancer, and other thoracic malignancies is central to this investigator’s portfolio, alongside studies in advanced and biomarker-defined lung cancer settings.
- Non-small cell lung cancer
- Small cell lung cancer
- Thoracic oncology
- Biomarker-directed lung cancer
Additional interest extends to bronchiectasis, cystic fibrosis, and interstitial lung disease, reflecting a strong therapeutic focus on respiratory disease management.
Interstitial Lung Disease and Pulmonary Hypertension
The investigator is involved in studies addressing fibrotic lung disease, idiopathic pulmonary fibrosis, and systemic autoimmune rheumatic disease-associated interstitial lung disease, with attention to progressive respiratory impairment.
- Idiopathic pulmonary fibrosis
- Progressive pulmonary fibrosis
- Systemic sclerosis–associated ILD
- Pulmonary arterial hypertension
Research also includes pulmonary hypertension associated with interstitial lung disease and related cardiopulmonary complications.
Autoimmune and Inflammatory Disease
Therapeutic activity includes systemic lupus erythematosus, Sjögren’s disease, idiopathic inflammatory myopathies, and systemic sclerosis, with a clear emphasis on immune-mediated disease control.
- Systemic lupus erythematosus
- Sjögren’s disease
- Idiopathic inflammatory myopathies
- Systemic sclerosis
Work also spans rheumatoid arthritis, ulcerative colitis, and Crohn’s disease, supporting broader interest in chronic inflammatory disorders.
Oncology Across Solid Tumors and Hematologic Malignancies
The investigator’s oncology research extends beyond the thorax to breast cancer, colorectal cancer, ovarian cancer, hepatocellular carcinoma, and biliary tract cancer, indicating broad engagement in solid-tumor therapeutics.
- Breast cancer
- Colorectal cancer
- Hepatocellular carcinoma
- Biliary tract cancer
Hematology-focused studies include acute myeloid leukemia, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, and multiple myeloma.
Cardiometabolic, Neurologic, and Rare Disease Interests
Additional clinical interests include heart failure, atrial fibrillation, stroke, Alzheimer’s disease, and Parkinson’s disease, showing involvement in complex cardiovascular and neurodegenerative conditions.
- Heart failure
- Atrial fibrillation
- Stroke
- Alzheimer’s disease
Rare disease activity includes Alport syndrome, congenital adrenal hyperplasia, Becker muscular dystrophy, and spinal muscular atrophy.
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