Álvaro L.
- Country
- Spain
- Department
- Pediatric Hematology-Oncology
Research Overview
- ONC201 for the Treatment of Newly Diagnosed H3 K27M-mutant Diffuse Glioma Following Completion of Radiotherapy: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study (The ACTION Study)
- Phase IB clinical trial to assess the safety, tolerability, and preliminary efficacy of AloCELYVIR (Mesenchymal allogenic cells + ICOVIR-5) in children, adolescent and young adults with newly diagnosed diffuse intrinsic pointine glioma (DIPG) in combination with radiotherapy or medulloblastoma in relapse/progression in monotherapy.
- Interfant-21: International collaborative treatment protocol for infants under one year with KMT2A-rearranged acute lymphoblastic leukemia or mixed phenotype acute leukemia
Data & Insights
Has run more than one trial at 165 of 269 partner sites.
Specializations
Pediatric Hematologic Malignancies
Clinical research in acute lymphoblastic leukemia, acute myeloid leukemia, and related high-risk relapsed or refractory blood cancers in children and adolescents, with attention to molecularly defined subgroups and treatment-resistant disease.
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
- Relapsed or refractory leukemia
- Hodgkin lymphoma and non-Hodgkin lymphoma
- Minimal residual disease
Active involvement also extends to Philadelphia chromosome-positive and FLT3-ITD disease, as well as pediatric lymphoma settings requiring targeted and immunologic approaches.
Solid Tumors and Central Nervous System Tumors
Investigator activity includes pediatric solid tumors and central nervous system tumors, especially aggressive or recurrent entities that require novel precision oncology strategies and tumor-directed immunotherapy.
- Neuroblastoma
- Medulloblastoma
- Diffuse midline glioma
- Ewing sarcoma and rhabdomyosarcoma
- ATRT and ependymoma
Therapeutic interests also include ALK-, BRAF-, and FGFR-altered tumors, together with relapsed or refractory extracranial and intracranial malignancies.
Immune-Mediated and Inflammatory Diseases
Research spans pediatric asthma, atopic dermatitis, food allergy, and other immune-mediated disorders, reflecting a strong therapeutic focus on allergic and inflammatory disease control in childhood.
- Severe asthma
- Atopic dermatitis
- Food allergy
- Crohn's disease and ulcerative colitis
- Systemic lupus erythematosus and psoriasis
Additional activity includes graft-versus-host disease, juvenile idiopathic arthritis, and uveitis, supporting work across pediatric autoimmune and inflammatory conditions.
Neurology and Rare Pediatric Genetic Disorders
Clinical trial involvement also covers epilepsy, developmental and epileptic encephalopathies, and syndromic neurologic diseases, alongside inherited metabolic and genetic conditions in pediatric care.
- Dravet syndrome and Lennox-Gastaut syndrome
- Tuberous sclerosis complex-related epilepsy
- Rett syndrome
- Fanconi anemia
- Pyruvate kinase deficiency and MPS II
Interest also includes gene therapy follow-up, hematopoietic stem cell-based approaches, and long-term management of rare inherited disease.
Transplantation, Cellular Therapy, and Advanced Immunotherapy
Research activity includes cellular therapy, CAR T-cell follow-up, and transplant-related complications, with emphasis on refractory malignancy and immune toxicity in pediatric and young adult populations.
- Chronic and acute graft-versus-host disease
- Gene-modified T cells
- CD22-positive and CD20-positive B-cell malignancies
- Relapsed or refractory mature B-cell neoplasms
- Post-transplant viral infection and immune complications
Therapeutic domains also include bispecific antibodies, checkpoint inhibition, and other immuno-oncology strategies for difficult-to-treat pediatric cancers.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.