Alvaro D. G.
- Country
- Spain
- Department
- Digestive Diseases
Research Overview
- Evaluation of Long-Term Safety and Tolerability of Seladelpar in Patients with Primary Biliary Cholangitis
- Evaluation of Pharmacokinetics, Safety, and Efficacy of Golexanolone in Primary Biliary Cholangitis Patients with Fatigue and Cognitive Dysfunction
- Efficacy and Safety Evaluation of Elafibranor in Primary Biliary Cholangitis Patients with Inadequate Ursodeoxycholic Acid Response: A Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 44 of 121 partner sites.
Specializations
Hepatology and metabolic liver disease
Clinical research activity is centered on chronic and progressive liver disorders, with a strong focus on non-alcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis, fatty liver disease, and liver fibrosis. The portfolio also extends to cholestatic and inflammatory liver conditions.
- Non-alcoholic steatohepatitis
- Metabolic dysfunction-associated steatohepatitis
- Primary biliary cholangitis
- Alcohol-related liver disease
- Compensated cirrhosis
Additional interest includes portal hypertension, hepatocellular carcinoma, and advanced chronic liver disease.
Gastrointestinal oncology
The investigator is involved in trials across a broad range of digestive tract malignancies, particularly tumors of the stomach, gastroesophageal junction, esophagus, colon, rectum, and pancreas. Work also includes biliary and hepatobiliary cancers.
- Colorectal cancer
- Gastric cancer
- Esophageal cancer
- Pancreatic cancer
- Biliary tract cancer
Research interest also covers gastroesophageal adenocarcinoma, neuroendocrine tumors, and advanced gastrointestinal neoplasms.
Immune-mediated disease and rheumatology
Clinical studies include multiple autoimmune and inflammatory disorders, with emphasis on rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus, and Sjögren’s syndrome. Additional activity is seen in connective tissue and vasculitic diseases.
- Rheumatoid arthritis
- Psoriatic arthritis
- Systemic lupus erythematosus
- Sjögren’s syndrome
- Systemic sclerosis
Other areas include idiopathic inflammatory myopathy, giant cell arteritis, and ANCA-associated vasculitis.
Hematologic malignancies
The investigator participates in studies involving a wide spectrum of blood cancers, especially multiple myeloma, lymphoma, and acute leukemias. The portfolio also includes relapsed and refractory disease settings across B-cell and plasma cell disorders.
- Multiple myeloma
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Chronic lymphocytic leukemia
- Acute lymphoblastic leukemia
Additional interest includes Hodgkin lymphoma, mantle cell lymphoma, and myelodysplastic syndromes.
Cardiopulmonary and renal disease
Research activity also spans cardiovascular, pulmonary, and kidney disorders, including atherosclerotic cardiovascular disease, acute myocardial infarction, pulmonary arterial hypertension, chronic obstructive pulmonary disease, and interstitial lung disease. Renal involvement includes transplant-related and chronic kidney conditions.
- Atherosclerotic cardiovascular disease
- Acute myocardial infarction
- Pulmonary arterial hypertension
- Chronic obstructive pulmonary disease
- Chronic kidney disease
Additional domains include pulmonary fibrosis, heart failure risk reduction, and kidney transplant rejection.
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