Alice G.
- Country
- France
- Department
- Service d'Hématologie Clinique
Research Overview
- Evaluation of DFV890 for Safety, Tolerability, and Efficacy in Patients with Myeloid Diseases
- Phase II Study of Imetelstat Sodium in High‑Risk MDS and AML Patients Refractory to Hypomethylating Agent Therapy
- Evaluation of Venetoclax and Azacitidine Combination Therapy Versus Placebo and Azacitidine in Treatment-Naïve Patients with Higher-Risk Myelodysplastic Syndrome
Data & Insights
Has run more than one trial at 101 of 233 partner sites.
Specializations
Hematologic Malignancies
Clinical research activity is centered on acute leukemia, chronic lymphocytic leukemia, lymphoma, and multiple myeloma, with additional involvement in myelodysplastic syndromes and myeloproliferative neoplasms. The portfolio also includes studies in mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and Waldenström macroglobulinemia.
- Acute myeloid leukemia
- Chronic lymphocytic leukemia
- Multiple myeloma
- Non-Hodgkin lymphoma
- Myelodysplastic syndromes
The work is closely aligned with allogeneic hematopoietic stem cell transplantation and graft-versus-host disease, reflecting a strong therapeutic focus on advanced blood cancers and post-transplant care.
Thoracic and Solid Tumors
Research spans a broad range of solid tumors, with notable involvement in non-small cell lung cancer, small cell lung cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, urothelial carcinoma, and breast cancer. Additional interest extends to head and neck squamous cell carcinoma, melanoma, and neuroendocrine tumors.
- Non-small cell lung cancer
- Colorectal cancer
- Hepatocellular carcinoma
- Breast cancer
- Urothelial carcinoma
Therapeutic interest includes both locally advanced and metastatic disease, with attention to targeted therapy and immunotherapy across multiple tumor types.
Autoimmune and Inflammatory Diseases
Clinical trial activity includes rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, vasculitis, Crohn’s disease, ulcerative colitis, atopic dermatitis, and psoriasis. The portfolio also covers giant cell arteritis, systemic sclerosis, and eosinophilic granulomatosis with polyangiitis.
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Crohn’s disease
- Ulcerative colitis
- Atopic dermatitis
The therapeutic emphasis is on immune-mediated conditions requiring long-term disease control, including biologic therapy and other advanced anti-inflammatory approaches.
Transplantation and Cellular Therapy
There is sustained involvement in hematopoietic stem cell transplantation, allograft management, and complications such as acute graft-versus-host disease and chronic graft-versus-host disease. Research also touches on CAR T-cell therapy and supportive strategies for transplant recipients.
- Hematopoietic stem cell transplantation
- Acute graft-versus-host disease
- Chronic graft-versus-host disease
- CAR T-cell therapy
- Transplant-related complications
This area reflects a therapeutic focus on improving outcomes in high-risk hematologic disease through transplant-based and cellular treatment strategies.
Cardiovascular, Renal, and Infectious Diseases
The investigator is also involved in studies of acute myocardial infarction, heart failure, atrial fibrillation, stroke, chronic kidney disease, and IgA nephropathy. Infectious disease activity includes COVID-19, pneumonia, candidemia, and viral infections.
- Acute myocardial infarction
- Heart failure
- Chronic kidney disease
- IgA nephropathy
- COVID-19
These studies indicate interest in cardiorenal disease, critical care, and infection-related complications in medically complex adult patients.
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