Alice B. T.
- Country
- France
- Department
- n/a
Research Overview
- Phase Ib/II Study of AMO959 with Lutetium (177Lu) Vipivotide Tetraxetan and Combination Therapy in Patients with PSMA-Positive Metastatic Castration-Resistant Prostate Cancer
- Efficacy and Safety of Capivasertib Plus Abiraterone in PTEN-Deficient Metastatic Hormone-Sensitive Prostate Cancer: A Phase III Randomized, Double-Blind, Placebo-Controlled Trial
- C2321008: A PHASE 3, RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED STUDY OF MEVROMETOSTAT (PF-06821497) WITH ENZALUTAMIDE IN METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER (MEVPRO-3)
Data & Insights
Has run more than one trial at 45 of 207 partner sites.
Specializations
Haematologic Malignancies
Clinical research is centered on relapsed and refractory blood cancers, with a strong focus on acute myeloid leukemia, myelodysplastic syndromes, acute lymphoblastic leukemia, and aggressive B-cell lymphomas. The portfolio also includes chronic lymphocytic leukemia, multiple myeloma, and other advanced hematologic neoplasms.
- Acute myeloid leukemia and myelodysplastic syndromes
- Acute lymphoblastic leukemia and acute leukemias
- Diffuse large B-cell lymphoma and related lymphomas
- Multiple myeloma and chronic lymphocytic leukemia
Work in this area reflects interest in targeted therapy, immunotherapy, and cell-based treatment strategies for difficult-to-treat blood cancers.
Thoracic and Lung Cancer
The investigator is actively involved in studies of non-small cell lung cancer, small cell lung cancer, and other thoracic malignancies, including biomarker-defined disease such as EGFR-mutated, ALK-positive, ROS1-positive, RET-altered, and HER2-altered tumors. Research also extends to mesothelioma and selected esophageal cancer settings.
- Non-small cell lung cancer
- Small cell lung cancer
- Mesothelioma
- Esophageal and thoracic solid tumors
Therapeutic interests include antibody-drug conjugates, immune checkpoint inhibition, and molecularly guided treatment for advanced thoracic disease.
Breast and Gynecologic Oncology
Research activity includes breast cancer across hormone receptor-positive, HER2-positive, HER2-low, and triple-negative subtypes, with attention to early, locally advanced, and metastatic disease. The gynecologic portfolio covers ovarian cancer, endometrial cancer, cervical cancer, fallopian tube cancer, and primary peritoneal cancer.
- Breast cancer subtypes
- Ovarian and primary peritoneal cancer
- Endometrial cancer
- Cervical and fallopian tube malignancies
The therapeutic focus includes hormonal therapy, PARP inhibition, HER2-directed treatment, and immunotherapy in advanced female cancers.
Gastrointestinal and Hepatobiliary Tumors
Clinical interests extend to colorectal cancer, gastric cancer, gastroesophageal junction adenocarcinoma, pancreatic ductal adenocarcinoma, and biliary tract cancer. The research landscape also includes hepatocellular carcinoma, gastrointestinal stromal tumor, and selected neuroendocrine tumors.
- Colorectal cancer
- Gastric and gastroesophageal junction cancer
- Pancreatic cancer
- Hepatobiliary malignancies
These studies emphasize precision oncology, immune-based treatment, and molecularly targeted therapy for advanced gastrointestinal cancers.
Sarcoma, Melanoma, and Rare Solid Tumors
The investigator also works across soft tissue sarcoma, bone sarcoma, melanoma, head and neck squamous cell carcinoma, urothelial carcinoma, and other rare or biomarker-selected solid tumors. This includes tumors defined by alterations such as KRAS, FGFR, MTAP, and SMARCA4.
- Soft tissue and bone sarcomas
- Melanoma
- Head and neck squamous cell carcinoma
- Urothelial and rare molecularly defined solid tumors
Therapeutic interests include novel immunotherapy combinations, targeted agents, and treatments for rare cancer subtypes with unmet clinical need.
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