Clinical Research
person

Alfredo S. H.

Country
Spain
Department
4th Department of Medical Oncology

Research Overview

assignment
18
Clinical Trials ·
location_city
3
Research Sites

Data & Insights

medical_services
Primary Speciality
Main therapeutic area

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Return Partnerships
Recurring site collaborations
244
Sites with multiple studies

Has run more than one trial at 244 of 485 partner sites.

Specializations

Thoracic Oncology

Clinical research in non-small cell lung cancer and small cell lung cancer, with interest in advanced disease, first-line treatment, locally advanced unresectable disease, and lung cancer with PD-L1 expression or brain metastasis. The oncology portfolio also extends to HER2-positive breast cancer, triple negative breast cancer, and metastatic breast cancer.

  • Advanced non-small cell lung cancer
  • Small cell lung cancer
  • HER2-positive and HER2-negative breast cancer
  • Metastatic and locally advanced solid tumors

Additional activity includes prostate cancer, bladder cancer, ovarian cancer, and colorectal cancer, reflecting a broad focus on solid tumor therapeutics and precision oncology.

Urologic and Prostate Cancer

Research involvement includes high-risk localized prostate cancer, metastatic castration-resistant prostate cancer, metastatic castration-sensitive prostate cancer, and castration-resistant prostate cancer. The bladder cancer program spans non-muscle invasive bladder cancer, high-risk non-muscle invasive bladder cancer, and tumors with FGFR alterations.

  • High-risk localized prostate cancer
  • Metastatic castration-resistant prostate cancer
  • Non-muscle invasive bladder cancer
  • FGFR-altered urothelial malignancy

Therapeutic interests also include renal cell carcinoma and urothelial carcinoma, supporting work in targeted and intravesical cancer treatment strategies.

Autoimmune and Inflammatory Disease

Clinical trial activity covers systemic lupus erythematosus, cutaneous lupus erythematosus, Sjögren’s syndrome, and psoriatic arthritis. The autoimmune portfolio also includes subacute cutaneous lupus erythematosus, chronic cutaneous lupus erythematosus, and related systemic and skin-dominant disease presentations.

  • Systemic lupus erythematosus
  • Cutaneous lupus erythematosus
  • Sjögren’s syndrome
  • Psoriatic arthritis

Additional interest is seen in homologous recombination repair-linked breast and prostate cancer contexts, alongside immune-mediated conditions requiring targeted anti-inflammatory therapy.

Allergy, Asthma, and Immunotherapy

Research includes allergic rhinitis, rhinoconjunctivitis, and asthma, particularly disease driven by house dust mite, grass pollen, and olive pollen sensitization. The investigator is also involved in studies of allergen standardization and immunotherapy for respiratory allergy.

  • House dust mite allergy
  • Allergic rhinoconjunctivitis
  • Asthma
  • Grass and olive pollen immunotherapy

Work in this area also extends to allergen extract development and sublingual or subcutaneous immunotherapy approaches for persistent allergic disease.

Sleep, Cardiovascular, and Other Medical Conditions

Additional clinical interests include narcolepsy with and without cataplexy, acute pulmonary embolism, spontaneous coronary artery dissection, and cardiovascular prevention in chronic kidney disease. The portfolio also covers mechanical ventilation weaning and respiratory support.

  • Narcolepsy type 1 and type 2
  • Acute pulmonary embolism
  • Spontaneous coronary artery dissection
  • Chronic kidney disease-related cardiovascular risk

Further activity includes bone fragility and vertebral fracture prevention, expanding the therapeutic scope beyond oncology and immune-mediated disease.

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