Alfonso V. R.
- Country
- Spain
- Department
- Cardiology
Research Overview
- Evaluation of Sacubitril/Valsartan on Systolic Function in Transthyretin Cardiac Amyloidosis and Heart Failure with Reduced Ejection Fraction
- Efficacy and Safety Evaluation of Eplontersen in Transthyretin-Mediated Amyloid Cardiomyopathy: A Phase 3 Double-Blind, Randomized, Placebo-Controlled Study
- Evaluation of Finerenone Efficacy and Safety in Heart Failure Patients with Reduced Ejection Fraction Intolerant or Ineligible for Steroidal Mineralocorticoid Receptor Antagonists
Data & Insights
Has run more than one trial at 58 of 332 partner sites.
Specializations
Cardiovascular disease and heart failure
The investigator is active in studies of atherosclerotic cardiovascular disease, acute coronary syndrome, myocardial infarction, atrial fibrillation, and stroke prevention, with further involvement in heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, and transthyretin amyloid cardiomyopathy.
- ASCVD and elevated lipoprotein(a)
- Atrial fibrillation and thromboembolic risk
- Heart failure and cardiomyopathy
- Acute myocardial infarction and post-event risk reduction
Research activity also extends to hypertension, dyslipidemia, aortic stenosis, and inherited dilated cardiomyopathy risk.
Oncology and hematologic malignancies
The clinical portfolio includes a broad range of solid and blood cancers, with emphasis on breast cancer, non-small cell lung cancer, prostate cancer, ovarian cancer, and urothelial carcinoma, alongside multiple lymphoma and myeloma settings.
- Breast cancer, including HER2-negative and triple-negative disease
- Non-small cell lung cancer and other thoracic tumors
- Multiple myeloma and lymphoma
- Prostate cancer and urothelial cancer
Additional interest is seen in melanoma, head and neck cancer, pancreatic cancer, and other advanced solid tumors.
Autoimmune, inflammatory, and rheumatic diseases
Investigations cover immune-mediated conditions such as rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus, systemic sclerosis, and Sjögren’s disease.
- Rheumatoid arthritis and juvenile idiopathic arthritis
- Psoriatic arthritis and plaque psoriasis
- Systemic lupus erythematosus and lupus nephritis
- Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis
Further work includes hidradenitis suppurativa, giant cell arteritis, and other chronic immune disorders.
Respiratory, ophthalmic, and endocrine-metabolic disorders
The investigator also contributes to studies in asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, bronchiectasis, and pulmonary hypertension, together with selected eye and metabolic conditions.
- Asthma and chronic obstructive pulmonary disease
- Idiopathic pulmonary fibrosis and progressive pulmonary fibrosis
- Thyroid eye disease and age-related macular degeneration
- Metabolic dysfunction-associated steatohepatitis and obesity
Interest also includes diabetes, dyslipidemia, and familial hypercholesterolemia.
Neurology, renal, and rare diseases
Clinical research involvement extends to multiple sclerosis, amyotrophic lateral sclerosis, myasthenia gravis, epilepsy, and other neurologic disorders, as well as kidney disease and selected inherited metabolic conditions.
- Multiple sclerosis and progressive neurologic disease
- Myasthenia gravis and related neuromuscular disease
- IgA nephropathy and other glomerular disorders
- Rare metabolic and genetic disorders
Additional areas include paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and transthyretin-mediated amyloidosis.
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