Alfonso Jose C. J.
- Country
- Spain
- Department
- Geriatría
Research Overview
Data & Insights
Has run more than one trial at 0 of 2 partner sites.
Specializations
Oncologic Therapeutics
The investigator engages in clinical evaluation of targeted and systemic treatments for a broad spectrum of solid tumors and hematologic malignancies.
- Breast cancer (hormone‑receptor positive, HER2‑negative, and triple‑negative subtypes)
- Lung cancer (non‑small cell, small cell, and KRAS‑mutant variants)
- Colorectal cancer (microsatellite instability‑high and KRAS/NRAS wild‑type)
- Renal cell carcinoma (clear cell and non‑clear cell forms)
- Hematologic malignancies (multiple myeloma, non‑Hodgkin lymphoma, acute myeloid leukaemia)
All studies are coordinated through Hospital Universitario Ramón y Cajal in Madrid, Spain.
Cardiovascular and Metabolic Medicine
Clinical work focuses on disease processes that drive morbidity in older adults, emphasizing prevention and management of cardiovascular disease and metabolic disorders.
- Atherosclerotic cardiovascular disease and elevated lipoprotein(a)
- Heart failure (preserved and reduced ejection fraction)
- Myocardial infarction (ST‑elevation and non‑ST‑elevation)
- Type 2 diabetes mellitus and obesity
- Chronic liver disease with acute decompensation (ACLF)
Research activities are conducted at the same Madrid‑based academic hospital.
Neurodegenerative and Cognitive Disorders
Investigations target progressive neurodegenerative conditions that disproportionately affect the elderly population.
- Alzheimer's disease and mild cognitive impairment
- Parkinson's disease with motor fluctuations
- Multiple sclerosis (relapsing‑remitting and progressive forms)
- Amyotrophic lateral sclerosis
- Frontotemporal dementia
The clinical trials are hosted at Hospital Universitario Ramón y Cajal.
Infectious and Immunologic Diseases
Efforts include therapeutic assessment of infections and immune‑mediated conditions prevalent in older adults.
- Nontuberculous mycobacterial infection (Mycobacterium avium complex)
- COVID‑19 and post‑viral sequelae
- Human immunodeficiency virus infection
- Autoimmune diseases (myasthenia gravis, systemic lupus erythematosus, vasculitis)
- Chronic fungal infections (aspergillosis, candidemia)
All investigations are performed within the Ramón y Cajal research infrastructure.
Geriatric Medicine and Age‑Related Syndromes
Specialized focus on comprehensive care models addressing the complex health needs of older adults.
- Geriatric syndromes (frailty, falls, delirium)
- Malnutrition and sarcopenia in the elderly
- Polypharmacy management and deprescribing
- Age‑related immune dysfunction (immunosenescence)
- Chronic kidney disease in the geriatric population
These programs are integrated into the Department of Geriatría at Hospital Universitario Ramón y Cajal, Madrid.
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