Alfonso D. C. B.
- Country
- Spain
- Department
- Servicio de Otorrinolaringología
Research Overview
- Efficacy, Safety, and Tolerability of Itepekimab in Chronic Rhinosinusitis Without Nasal Polyps: A Randomized, Double-Blind, Placebo-Controlled Study
- Phase 3b Multicenter Study on Tezepelumab for Symptom Modulation in Chronic Rhinosinusitis with Nasal Polyposis
- Phase 3 Evaluation of Itepekimab Efficacy and Safety in Adults with Inadequately-Controlled Chronic Rhinosinusitis with Nasal Polyps
Data & Insights
Has run more than one trial at 17 of 91 partner sites.
Specializations
Oncologic Therapeutics
The investigator focuses on innovative treatments for a broad spectrum of solid tumors, emphasizing targeted and immunologic strategies.
- Advanced breast cancer
- Advanced non‑small cell lung cancer
- Advanced ovarian and peritoneal cancers
- Advanced bladder cancer
- Advanced head and neck squamous cell carcinoma
Research is conducted at Hospital Jerez de la Frontera within the otorhinolaryngology department.
Hematologic Malignancies
He contributes to clinical investigations targeting blood‑borne cancers, with a particular interest in disease‑specific immunotherapy.
- Acute myeloid leukemia
- Multiple myeloma
- Diffuse large B‑cell lymphoma
- Essential thrombocythemia
- Myelofibrosis with low platelet counts
Studies integrate multidisciplinary expertise to advance therapeutic options for hematologic disease.
Respiratory Disorders
His work includes trials addressing chronic airway inflammation and infectious complications of the respiratory tract.
- Severe eosinophilic asthma
- Chronic rhinosinusitis with nasal polyps
- Moderate‑to‑severe chronic obstructive pulmonary disease
- Bronchiectasis associated with cystic fibrosis
- Allergic rhinoconjunctivitis
These studies aim to improve symptom control and disease progression in respiratory patients.
Cardiovascular Disease Management
He participates in investigations targeting atherosclerotic disease, coronary syndromes, and thrombosis prevention.
- Atherosclerotic cardiovascular disease
- Coronary artery disease
- Spontaneous coronary artery dissection
- Cancer‑associated thrombosis
- Venous thromboembolism prophylaxis in metastatic colorectal cancer
Efforts focus on reducing cardiovascular events and optimizing antithrombotic therapy.
Infectious Disease and Antimicrobial Strategies
His clinical portfolio includes trials evaluating treatment durations and novel agents for bacterial and viral infections.
- Pseudomonas aeruginosa bacteremia
- Enterobacteriaceae septicemia
- Enterococcal bacteremia
- HIV infection
- Cystic fibrosis antimicrobial therapy
These studies seek to refine antimicrobial regimens and improve patient outcomes.
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