Alfonso C. Ú.
- Country
- Spain
- Department
- Infectious Diseases
Research Overview
- Efficacy and Safety of Islatravir and Ulonivirine Once Weekly versus Bictegravir, Emtricitabine, and Tenofovir Alafenamide Once Daily in Treatment-Naïve Adults with HIV-1
- Lenacapavir with Teropavimab and Zinlirvimab (twice‑yearly) versus Cabotegravir/Rilpivirine in virologically suppressed adults with HIV‑1
- Cohort study of human mpox virus disease
Data & Insights
Has run more than one trial at 38 of 133 partner sites.
Specializations
Thoracic and lung oncology
Clinical research activity includes non-small cell lung cancer, small cell lung cancer, and other advanced thoracic malignancies, with interest in EGFR-mutated, KRAS-altered, and metastatic disease settings.
- Non-small cell lung cancer
- Small cell lung cancer
- EGFR-mutated lung cancer
- Advanced thoracic malignancies
Therapeutic focus extends to immunotherapy, targeted treatment, and combination approaches for advanced and unresectable lung cancer.
Hematologic malignancies
Research involvement covers acute myeloid leukemia, diffuse large B-cell lymphoma, chronic lymphocytic leukemia, follicular lymphoma, and other aggressive or relapsed blood cancers.
- Acute myeloid leukemia
- Diffuse large B-cell lymphoma
- Chronic lymphocytic leukemia
- Multiple myeloma
The therapeutic landscape includes cellular therapy, antibody-based strategies, and treatment options for refractory hematologic disease.
Genitourinary and renal disease
Active interests include urothelial carcinoma, bladder cancer, renal cell carcinoma, prostate cancer, and chronic kidney disorders such as IgA nephropathy and autosomal dominant polycystic kidney disease.
- Urothelial carcinoma
- Renal cell carcinoma
- Prostate cancer
- IgA nephropathy
Therapeutic emphasis includes oncology interventions alongside renal-protective and kidney-function-preserving treatments.
Gastrointestinal and hepatobiliary cancer
Clinical trial activity spans colorectal cancer, gastric cancer, pancreatic cancer, cholangiocarcinoma, and hepatocellular carcinoma, reflecting broad interest in digestive system malignancies.
- Colorectal cancer
- Gastric cancer
- Pancreatic cancer
- Hepatocellular carcinoma
Research also includes advanced solid tumors with biomarker-defined selection and immuno-oncology combinations in gastrointestinal cancers.
Immune-mediated and infectious diseases
Additional research interests include Crohn’s disease, multiple sclerosis, asthma, hidradenitis suppurativa, and HIV infection, alongside selected infectious and inflammatory conditions.
- Crohn’s disease
- Multiple sclerosis
- Asthma
- HIV infection
Therapeutic interests include immune modulation, anti-inflammatory treatment, and management of chronic infectious disease.
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