Alexandre K.
- Country
- France
- Department
- Nephrology
Research Overview
- A multicenter randomized trial to evaluate the efficacy of pioglitazone to promote renal tolerance in ANCA-associated vasculitis - RENATO
- PREP-ANCA: Randomized Trial of Pre‑emptive Rituximab Versus Clinic‑Biological Surveillance for ANCA Re‑positivation in GPA and MPA Patients in Remission
- Phase II Study of Obinutuzumab in Patients with Systemic Lupus Erythematosus Pure Membranous Nephropathy (Class V Lupus Nephritis)
Data & Insights
Has run more than one trial at 91 of 220 partner sites.
Specializations
Nephrology and Kidney Disease
The investigator is active in nephrology with a strong focus on chronic kidney disease, acute kidney injury, kidney transplant care, and immune-mediated renal disorders.
- IgA nephropathy and membranous nephropathy
- Focal segmental glomerulosclerosis and proteinuric kidney disease
- Lupus nephritis and systemic autoimmune renal disease
- Kidney transplant rejection and allograft dysfunction
Research interest also extends to APOL1-mediated kidney disease, Alport syndrome, autosomal dominant polycystic kidney disease, and renal complications linked to systemic inflammatory disease.
Autoimmune and Inflammatory Diseases
Clinical work includes a wide range of autoimmune disease and systemic inflammatory disorders, particularly conditions affecting the kidneys, lungs, joints, and connective tissues.
- ANCA-associated vasculitis and granulomatosis with polyangiitis
- Systemic lupus erythematosus and cutaneous lupus erythematosus
- Sjögren’s disease and IgG4-related disease
- Rheumatoid arthritis, psoriatic arthritis, and systemic sclerosis
He is also involved in studies of myositis, myasthenia gravis, sarcoidosis, and immune thrombocytopenia, reflecting broad expertise in immune-mediated therapeutic development.
Respiratory and Pulmonary Fibrosis
The investigator contributes to research in interstitial lung disease, idiopathic pulmonary fibrosis, and other chronic respiratory conditions with progressive fibrotic or inflammatory features.
- Interstitial lung disease and systemic sclerosis-associated ILD
- Idiopathic pulmonary fibrosis and progressive pulmonary fibrosis
- Pulmonary sarcoidosis and pulmonary hypertension
- Chronic obstructive pulmonary disease and bronchiectasis
Additional interest includes severe asthma, respiratory infections, and acute respiratory distress syndrome, with attention to therapies aimed at preserving lung function.
Oncology and Hematologic Malignancies
He is involved in extensive oncology research, with major activity in solid tumors and blood cancers across gastrointestinal, thoracic, urologic, and gynecologic malignancies.
- Colorectal cancer, gastric cancer, and hepatocellular carcinoma
- Non-small cell lung cancer and small cell lung cancer
- Renal cell carcinoma, urothelial carcinoma, and prostate cancer
- Acute myeloid leukemia, lymphoma, and multiple myeloma
Research also covers ovarian cancer, pancreatic cancer, melanoma, and head and neck cancer, with interest in treatment strategies that expand options for advanced and refractory disease.
Cardiometabolic, Critical Care, and Infectious Disease
The investigator’s portfolio includes cardiovascular disease, metabolic disorders, critical care, and infectious diseases relevant to hospitalized and high-risk adult patients.
- Acute coronary syndrome, heart failure, and atrial fibrillation
- Sepsis, septic shock, and intensive care medicine
- HIV infection, hepatitis B, and hepatitis C
- Thromboembolism and hypertension
Further activity includes type 2 diabetes, obesity, liver disease, and acute infection prophylaxis, supporting therapeutic innovation in complex multisystem care.
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