Alessandra M.
- Country
- Italy
- Department
- UOSD Epatologia
Research Overview
- A Phase IIa, Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety, Tolerability, and Pharmacodynamics of AZD4831 in Participants with Non-cirrhotic Non-alcoholic Steatohepatitis (NASH) with Fibrosis
- Phase 3 Randomized Double-Blind Placebo-Controlled Trial of Efruxifermin in Non-Cirrhotic NASH/MASH with Fibrosis
- Phase 3 Multinational Study of Resmetirom in Non-Alcoholic Steatohepatitis Patients to Assess NASH Resolution and Fibrosis Progression Prevention
Data & Insights
Has run more than one trial at 100 of 257 partner sites.
Specializations
Hepatology and metabolic liver disease
The investigator is active in clinical research on non-alcoholic steatohepatitis (NASH), metabolic dysfunction-associated steatohepatitis (MASH), non-alcoholic fatty liver disease (NAFLD), and cirrhosis related to chronic liver injury, with interest in liver fibrosis and liver-related clinical outcomes.
- NASH and MASH
- NAFLD
- Liver fibrosis and cirrhosis
- Primary biliary cholangitis and primary sclerosing cholangitis
Research activity also includes therapies aimed at modifying liver histology and preventing progression to advanced liver disease.
Inflammatory bowel disease
The investigator is involved in studies focused on Crohn’s disease, ulcerative colitis, and broader inflammatory bowel disease, with emphasis on symptom control, mucosal healing, and disease modification.
- Crohn’s disease
- Ulcerative colitis
- Transmural healing
- Therapeutic drug monitoring
Clinical interests extend to treatment strategies for moderately to severely active disease and fistulizing intestinal inflammation.
Hematologic malignancies and transplant-related disorders
Clinical research involvement includes acute myeloid leukemia, acute lymphoblastic leukemia, multiple myeloma, and lymphoma, together with complications linked to hematopoietic stem cell transplantation.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Multiple myeloma
- Diffuse large B-cell lymphoma
Additional interests include graft-versus-host disease, thrombotic microangiopathy, and relapse prevention in high-risk hematologic settings.
Solid tumors and gastrointestinal oncology
The investigator participates in trials in colorectal cancer, gastric cancer, cholangiocarcinoma, pancreatic cancer, and melanoma, with a strong focus on advanced and metastatic disease.
- Metastatic colorectal cancer
- Gastric and gastroesophageal junction cancer
- Cholangiocarcinoma
- Advanced melanoma
Research also covers biomarker-driven treatment selection and targeted approaches in gastrointestinal and hepatobiliary oncology.
Kidney disease, autoimmune disorders, and neurology
The investigator is also engaged in studies on chronic kidney disease, IgA nephropathy, type 2 diabetes, generalized myasthenia gravis, and selected neurodegenerative or neurological conditions.
- Chronic kidney disease
- IgA nephropathy
- Generalized myasthenia gravis
- Huntington’s disease
Therapeutic interests include renal protection, immune-mediated disease control, and symptom-directed treatment in chronic neurologic illness.
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