Alessandra D.
- Country
- Italy
- Department
- Hematology
Research Overview
Data & Insights
Has run more than one trial at 0 of 9 partner sites.
Specializations
Acute Myeloid Leukemia
Focused on molecularly defined subgroups of Acute Myeloid Leukemia and integration of measurable residual disease (MRD) strategies to guide intensive and transplant‑based therapies.
- FLT3‑mutated AML
- NPM1‑mutated AML
- Secondary AML arising from myeloproliferative neoplasms
- MRD‑guided treatment escalation
- Allogeneic stem cell transplantation
Efforts aim to refine risk‑adapted regimens and improve long‑term remission rates.
Acute Lymphoblastic Leukemia
Investigates adult and pediatric Acute Lymphoblastic Leukemia with emphasis on cytogenetic subtypes and targeted immunotherapies.
- Philadelphia chromosome‑positive ALL
- B‑cell precursor ALL
- T‑cell ALL
- MRD‑negative remission endpoints
- Novel monoclonal antibodies and bispecific constructs
Research supports precision approaches to reduce relapse risk.
B‑cell and T‑cell Lymphomas
Broad activity across mature and aggressive lymphoid neoplasms, integrating biologic classification with emerging therapeutic agents.
- Diffuse large B‑cell lymphoma (DLBCL)
- Mantle cell lymphoma
- Follicular lymphoma
- Marginal zone lymphoma
- Peripheral T‑cell lymphoma
Clinical programs evaluate chemo‑immunotherapy combinations and targeted pathway inhibitors.
Myelodysplastic Syndromes & Myeloproliferative Neoplasms
Targets clonal hematopoietic disorders including Myelodysplastic Syndromes and related proliferative conditions.
- High‑risk MDS
- Chronic myelomonocytic leukemia (CMML)
- Primary myelofibrosis
- Polycythemia vera
- Anemia management and transfusion independence
Studies explore disease‑modifying agents and transplant eligibility criteria.
Cardiovascular & Thrombotic Disorders
Extends expertise to vascular and arrhythmic conditions, focusing on prevention of ischemic events and thrombosis.
- Atherosclerotic cardiovascular disease
- Atrial fibrillation
- Ischemic stroke
- Venous thromboembolism
- Anticoagulation and antiplatelet strategies
Research seeks to balance efficacy and bleeding risk in high‑risk populations.
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