Alessandra C.
- Country
- Italy
- Department
- Oncologia
Research Overview
- Evaluation of Palonosetron and Netupitant as Antiemetic Therapy in Chemotherapy-Naïve Endometrial Cancer Patients Receiving Paclitaxel-Carboplatin Regimen.
- Phase III Randomized Trial of Niraparib and Dostarlimab Versus Physician's Choice Chemotherapy in Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
- Phase III Randomized Study of Niraparib Monotherapy Versus Niraparib and Bevacizumab Combination in Advanced High-Grade Epithelial Ovarian Cancer
Data & Insights
Has run more than one trial at 25 of 158 partner sites.
Specializations
Ovarian cancer and gynecologic oncology
Clinical activity in advanced epithelial ovarian cancer, platinum-resistant ovarian cancer, platinum-sensitive relapse, and endometrial cancer, with interest in maintenance therapy, targeted treatment, and biomarker-defined disease.
- HRD-positive ovarian cancer
- FRα-high recurrent ovarian cancer
- Low-grade serous ovarian carcinoma
- Locally advanced cervical cancer
- Endometrial cancer
Research also includes PARP inhibitor-based strategies, anti-angiogenic therapy, and biomarker-guided approaches in recurrent and newly diagnosed gynecologic malignancies.
Breast cancer and hormone-sensitive disease
Work in early breast cancer, metastatic breast cancer, and triple-negative breast cancer, with emphasis on HER2-positive and HR-positive subtypes and endocrine-sensitive disease.
- HER2-positive early breast cancer
- HR-positive/HER2-negative breast cancer
- Metastatic triple-negative breast cancer
- Chemo-induced cardiotoxicity in breast cancer
Therapeutic interests include endocrine therapy, antibody-based treatment, and treatment strategies linked to molecular risk assessment.
Cardiovascular disease and thromboembolic prevention
Clinical research spans atrial fibrillation, stroke, heart failure, cardiovascular risk reduction, and prevention of venous thromboembolism.
- Atrial fibrillation
- Acute ischemic stroke
- Heart failure
- Established cardiovascular disease
- Venous thromboembolism prevention
Additional focus includes anticoagulation, atherosclerotic cardiovascular disease, and therapies aimed at reducing major adverse cardiovascular events.
Kidney disease and complement-mediated disorders
Investigational work includes IgA nephropathy, membranous nephropathy, complement-mediated kidney disease, and chronic kidney disease, with attention to proteinuria and renal preservation.
- IgA nephropathy
- Primary membranous nephropathy
- C3 glomerulopathy
- Non-diabetic chronic kidney disease
- Atypical hemolytic uremic syndrome
Therapeutic interests extend to complement inhibition and kidney-focused treatment strategies in immune-mediated renal disease.
Inflammation, infectious disease, and perioperative care
Research involvement includes acute myocarditis, cardiac inflammation, Clostridioides difficile infection, influenza, and pregnancy-related complications.
- Acute myocarditis
- Severe cardiac inflammation
- Recurrent Clostridioides difficile infection
- Influenza prevention
- Premature rupture of membranes
Other interests include supportive and preventive care in perioperative, maternal, and infectious disease settings.
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