Alen Z.
- Country
- Italy
- Department
- SOC Clinica di Reumatologia
Research Overview
- A randomized, parallel-group, 24 week, double-blind, placebo-controlled, multicenter Phase 3 study to assess the efficacy and safety of secukinumab compared to placebo in adult patients with active rotator cuff tendinopathy
- Efficacy and Safety Evaluation of JNJ-77242113 in Biologic-Experienced Patients with Active Psoriatic Arthritis: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study
- Evaluation of Synovial Biomarkers for Predicting Response to Ixekizumab in Refractory Psoriatic Arthritis Patients
Data & Insights
Has run more than one trial at 29 of 193 partner sites.
Specializations
Hematologic Malignancies
Clinical research is centered on lymphoma, multiple myeloma, and related myeloid neoplasms, with involvement across both indolent and aggressive blood cancers.
- Follicular lymphoma
- Marginal zone lymphoma
- Diffuse large B-cell lymphoma
- Waldenström macroglobulinemia
- Acute myeloid leukemia
The therapeutic focus includes B-cell malignancies, plasma cell disorders, and lymphoproliferative diseases, supporting innovation in targeted and immune-based hematology care.
Autoimmune and Inflammatory Rheumatic Disease
Research activity includes psoriatic arthritis, Sjögren’s syndrome, systemic lupus erythematosus, systemic sclerosis, and idiopathic inflammatory myopathy.
- Psoriatic arthritis
- Sjögren’s syndrome
- Systemic lupus erythematosus
- Diffuse cutaneous systemic sclerosis
- Idiopathic inflammatory myopathy
The investigator’s therapeutic interests also extend to axial spondyloarthritis, myasthenia gravis, and primary biliary cholangitis, reflecting a broad involvement in immune-mediated disease treatment.
Solid Tumors and Precision Oncology
Clinical trial involvement spans breast cancer, lung cancer, gastroesophageal cancer, colorectal cancer, ovarian cancer, and melanoma, with attention to biomarker-selected disease.
- Breast cancer
- Non-small cell lung cancer
- Gastric and gastroesophageal junction adenocarcinoma
- Colorectal cancer
- Melanoma
Additional interests include hepatocellular carcinoma, esophageal carcinoma, and endometrial cancer, alongside therapies guided by molecular alterations and immune targeting.
Transplantation, Immune Complications, and Rare Disorders
Research also covers graft-versus-host disease, hematopoietic stem cell transplantation-related complications, and selected rare conditions such as mucopolysaccharidosis type II and partial lipodystrophy.
- Chronic graft-versus-host disease
- Hematopoietic stem cell transplant-associated thrombotic microangiopathy
- Mucopolysaccharidosis type II
- Partial lipodystrophy
- Hemophilia A and hemophilia B
Therapeutic interests further include invasive candidiasis, cytomegalovirus infection, and other complex immune-related or inherited disorders requiring specialized clinical management.
Cardiometabolic, Neurologic, and Ophthalmic Conditions
The investigator is also involved in studies of heart failure, ischemic stroke, transient ischemic attack, multiple sclerosis, and retinal diseases such as diabetic macular edema and neovascular age-related macular degeneration.
- Heart failure
- Acute ischemic stroke and high-risk transient ischemic attack
- Relapsing forms of multiple sclerosis
- Diabetic macular edema
- Neovascular age-related macular degeneration
Additional therapeutic areas include hypertension, thrombosis prevention, and obesity-related disease, broadening the clinical landscape beyond oncology and rheumatology.
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