Alejandro Luis C. G.
- Country
- Spain
- Department
- Hematology
Research Overview
- Phase 3 Study of Oral Arsenic Trioxide QTX-2101 in Newly Diagnosed Low-Risk Acute Promyelocytic Leukemia
- Evaluation of RVU120 Monotherapy in Relapsed/Refractory High-Risk Myelodysplastic Syndrome and Acute Myeloid Leukemia with/without NPM1 Mutation
- Evaluation of RVU120 and Venetoclax Combination Therapy in Acute Myeloid Leukemia Patients Refractory to Prior Venetoclax and Hypomethylating Agent Treatment
Data & Insights
Has run more than one trial at 64 of 190 partner sites.
Specializations
Thoracic Oncology
Clinical research activity includes non-small cell lung cancer, small cell lung cancer, and other advanced solid tumors, with interest in molecularly defined disease such as EGFR-mutated, ALK-positive, ROS1-rearranged, RET-fusion positive, and KRAS G12C-mutant malignancies.
- Advanced and metastatic lung cancer
- Biomarker-selected solid tumors
- Head and neck squamous cell carcinoma
- Gastroesophageal and pancreatic cancers
Research also extends to melanoma, colorectal cancer, breast cancer, and urothelial carcinoma, reflecting broad involvement in oncology care at Hospital Universitario Regional De Malaga.
Hematologic Malignancies and Transplantation
The investigator is active in acute myeloid leukemia, acute lymphoblastic leukemia, multiple myeloma, chronic lymphocytic leukemia, mantle cell lymphoma, and myelodysplastic syndrome, alongside studies in hematopoietic stem cell transplantation and post-transplant complications.
- Leukemia and lymphoma
- Plasma cell disorders
- Graft-versus-host disease
- Transplant-related infections and microangiopathy
Additional interest includes gene-modified T-cell follow-up, cytomegalovirus infection in transplant recipients, and neutropenia associated with intensive hematologic treatment.
Autoimmune and Inflammatory Diseases
Research involvement covers rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, systemic sclerosis, Sjögren’s syndrome, and idiopathic inflammatory myopathy, with parallel work in immune-mediated organ disease.
- Systemic autoimmune disorders
- Inflammatory arthritis
- Connective tissue disease
- Immune-mediated kidney disease
Therapeutic interest also includes bullous pemphigoid, chronic spontaneous urticaria, myasthenia gravis, and multiple sclerosis, highlighting a strong focus on immune modulation across organ systems.
Neurology and Neuroimmunology
Clinical trial activity includes multiple sclerosis in relapsing and progressive forms, amyotrophic lateral sclerosis, epilepsy syndromes, Parkinson’s disease, and autoimmune encephalitis.
- Relapsing and progressive demyelinating disease
- Seizure disorders
- Neurodegenerative disease
- Autoimmune neurologic syndromes
Work in generalized myasthenia gravis, spinal muscular atrophy, Dravet syndrome, and tuberous sclerosis complex supports a broad therapeutic interest in chronic neurologic and neuromuscular conditions.
Cardiometabolic, Renal, and Respiratory Medicine
Research spans coronary artery disease, heart failure, atherosclerotic cardiovascular disease, type 2 diabetes, obesity, and hypertriglyceridemia, together with renal and pulmonary conditions.
- Cardiovascular prevention and ischemic disease
- Chronic kidney disease and nephropathies
- Asthma and chronic obstructive pulmonary disease
- Allergic rhinitis and food allergy
Therapeutic interests also include IgA nephropathy, focal segmental glomerulosclerosis, kidney transplant rejection, asthma, and allergic rhinoconjunctivitis, showing engagement in both chronic disease management and targeted innovation.
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