Alba Rubio S. S.
- Country
- Spain
- Department
- Pediatric
Research Overview
Data & Insights
Has run more than one trial at 0 of 1 partner site.
Specializations
Pediatric Hematologic Malignancies
The investigator focuses on malignant blood disorders in children, including Acute lymphoblastic leukemia, Acute myeloid leukemia, Chronic myeloid leukemia, as well as Non‑Hodgkin lymphoma and Hodgkin lymphoma.
- Relapsed Acute lymphoblastic leukemia
- FLT3‑ITD positive Acute myeloid leukemia
- Philadelphia chromosome‑positive Acute lymphoblastic leukemia
- CD22‑positive B‑cell precursor ALL
- Targeted therapy for Chronic myeloid leukemia
Research aims to improve survival and reduce treatment‑related toxicity in these high‑risk pediatric cancers.
Pediatric Solid Tumors & CNS Neoplasms
Work includes a broad spectrum of solid and central nervous system cancers such as Neuroblastoma, Rhabdomyosarcoma, Ewing sarcoma, Osteosarcoma, Medulloblastoma, Diffuse intrinsic pontine glioma, High‑grade glioma and ATRT.
- High‑risk Neuroblastoma
- Recurrent Rhabdomyosarcoma
- Molecularly stratified Ewing sarcoma
- Metastatic Osteosarcoma
- Refractory Medulloblastoma
Efforts target novel targeted agents and precision‑medicine strategies for these aggressive pediatric tumors.
Pediatric Immunology & Allergic Diseases
Investigation of immune‑mediated and allergic conditions such as Asthma, Atopic dermatitis, Food allergy, Severe cow's milk allergy and Allergic rhinoconjunctivitis is a core area.
- Biologic therapy for moderate‑to‑severe Asthma
- Long‑term safety of biologics in Atopic dermatitis
- Desensitization strategies for Peanut allergy
- Management of Severe cow's milk allergy
- Treatment of Allergic rhinoconjunctivitis
The focus is on improving disease control and quality of life for pediatric patients.
Genetic & Metabolic Disorders in Children
Research addresses inherited conditions including Fanconi anemia, Pyruvate kinase deficiency, Mucopolysaccharidosis type II, Neurofibromatosis type 1, Leukocyte adhesion deficiency‑I and pediatric Obesity.
- Gene therapy for Fanconi anemia
- Enzyme replacement in Mucopolysaccharidosis type II
- Metabolic correction in Pyruvate kinase deficiency
- Targeted treatment of Neurofibromatosis type 1 plexiform neurofibromas
- Management strategies for pediatric Obesity
These initiatives seek disease‑modifying therapies and supportive care advancements.
Transplant‑Related and Immune‑Mediated Conditions
The investigator also examines complications of transplantation and systemic immune disorders such as Graft‑versus‑host disease, Chronic graft‑versus‑host disease, Autoimmune refractory epilepsy, Systemic juvenile idiopathic arthritis, Systemic lupus erythematosus and pediatric Inflammatory bowel disease.
- Steroid‑refractory Acute graft‑versus‑host disease
- Long‑term outcomes after hematopoietic stem cell transplant in Graft‑versus‑host disease
- Novel immunotherapies for Systemic lupus erythematosus
- Biologic agents in Systemic juvenile idiopathic arthritis
- Management of pediatric Inflammatory bowel disease
Efforts are directed toward reducing transplant‑related morbidity and advancing immune‑modulating treatments.
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