Annette V. Z.
- Country
- The Netherlands
- Department
- Oncology
Research Overview
- Adjuvant Pembrolizumab Versus Capecitabine or Olaparib in Patients with Early-Stage Triple-Negative Breast Cancer with Residual Disease Following Neoadjuvant Therapy
- Phase III Multicenter Randomized Trial of Dose-Reduced Chemotherapy with Fluorouracil, Folinic Acid, Capecitabine, and Oxaliplatin in Metastatic Colorectal Cancer
- Evaluation of CDK4/6 Inhibitors Abemaciclib, Palbociclib, and Ribociclib in HR+/HER2- Metastatic Breast Cancer: A Randomized Clinical Trial
Data & Insights
Has run more than one trial at 66 of 70 partner sites.
Specializations
Advanced Breast Cancer Treatment
Focuses on innovative therapeutic approaches for hormone receptor-positive HER2-negative advanced breast cancer, particularly investigating treatment combinations involving endocrine therapy and targeted agents.
- PIK3CA-mutated breast cancer therapy
- CDK4/6 inhibition strategies
- Fulvestrant-based treatment sequences
Explores treatment options for both pre- and postmenopausal patients, emphasizing personalized therapeutic approaches.
Treatment Sequencing Studies
Investigates optimal sequencing of combination therapies in breast cancer treatment, with particular emphasis on aromatase inhibitors and targeted therapeutic agents.
- First-line treatment strategies
- Second-line therapy optimization
- Progression-free survival assessment
Evaluates treatment effectiveness across different therapeutic lines for metastatic disease management.
Colorectal Cancer Research
Specializes in metastatic colorectal cancer treatment approaches, with particular attention to dose optimization strategies for elderly patients.
- Chemotherapy dosing protocols
- Age-specific treatment adaptations
- Toxicity risk management
Develops personalized chemotherapy approaches considering individual patient characteristics and risk factors.
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